SiliaMetS® - Metal Scavengers Features and Benefits
SiliaMetS Metal Scavengers are functionalized silica gels designed to react and bind excess metal complexes. The process for using scavengers is outlined in the scheme below.
|Features & Benefits of SiliaMetS Metal Scavengers|
|No leaching||No API contamination by the metal scavenger|
|Very High Purity||Each SiliaMetS product manufactured is submitted to a very rigorous quality control in order to provide customers with default-free products and insure 100% satisfaction|
|High Selectivity||Total recovery of the API|
|Wide Range of Metal Affinities (various oxidation state)||Efficient for a wide range of metal catalysts|
|Fast Kinetic||Even at room temperature|
|Cost Efficient||Low cost per gram of metal scavenged
Less solvent used
|Solvent Compatibility||Can be used in any solvent, aqueous (pH 2 to 12) and organic|
|New Technologies Compatibility||Suitable for use in microwave synthesizers and flow chemistry|
|Excellent Stability (Thermally and Mechanically)||Works well with overhead stirring
Can withstand very high temperatures
|Ease of Use & Scalable||No swelling or static charge
Remove easily from a simple filtration
Scalable from mg up to multi-ton scale
|Flexible Formats||Amenable to use in SiliaSep & SiliaPrep Cartridges|
|Controlled Loading||Consistent and accurate loading insure lot-to-lot reproducibility|
|Available at Bulk Quantities||Proced in large quantities and always in stock|
SiliaMetS® Thiol (Si-Thiol) is a robust metal scavenger for a variety of metals including Pd, Pt, Cu, Ag and Pb under a wide range of conditions. It has been used in pharmaceutical processes up to the pilot plant scale. It is our most versatile metal scavenger and is the preferred metal scavenger for Pd(II), Cu, Ag, and Hg.
SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.
SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.
SiliaMetS® DMT (Si-DMT) is the silica bound equivalent of 2,4,6-trimercaptotriazine (trithiocyanuric acid). It is a versatile metal scavenger for a variety of metals including Cd, Co, Ni, Pd, Pt, Rh, and Ru under a wide range of conditions and the preferred metal scavenger for ruthenium catalysts.
TMT has been reported to efficiently remove palladium and heavy metals by precipitation. Unfortunately, its solubility in organic solvents causes problem. SiliaMetS DMT solves this issue and almost all solvents can now be used.
SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.
SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.