SiliaBond Amine-supported Cu nanoparticles: An efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddition (CuAAC)
Huisgen azide-alkyne cycloadditions are typically catalyzed by soluble copper salts. By immobilizing Cu on silica, a new catalyst was prepared which showed low leaching and good recyclability while retaining a high reactivity.
SiliaBond Amine can be used to immobilize Cu nanoparticles prepared by metal vapor synthesis. The resulting catalyst has been shown to be very active for both batch and continuous flow chemistry. The high productivity of the catalyst (up to 1689 mol/mol), its reusability and low metal leaching profile make it an attractive option for click chemistry applications. More over, its reaction scope was shown to be wide, opening the door to several 1,4-disubstituted-1,2,3-triazole scaffolds.
Keywords:
Copper, Click chemistry, Huisgen, SiliaBond Amine, Triazoles
Publication | Aminopropyl-silica-supported Cu nanoparticles: An efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddition (CuAAC) |
Authors | Ravindra P. Jumdea, Claudio Evangelistia, Alessandro Mandolia,b, Nicola Scottia, Rinaldo Psaroa |
Organization | a CNR, Institute of Molecular Science and Technologies (ISTM), Via G. Fantoli 16/15, 20138 Milan, Italy b Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 3, 56124 Pisa, Italy |
Source | Journal of Catalysis, Volume 324, April 2015, Pages 25–31 |
Date | 2015 |
Reaction scheme | |
Full publication | http://www.sciencedirect.com/science/article/pii/S002195171500024X |
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