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SiliaChrom HPLC Columns

SiliaChrom®- HPLC Columns

SiliCycle manufactures a variety of HPLC columns for reversed and normal phases applications. The SiliaChrom series contain more than 20 different phases produced in our own laboratories, and we continue to develop additional unique and powerful HPLC columns. In fact, you can be completely assured of the quality, from raw material synthesis through packing, testing and customer applications.

SiliaChrom HPLC columns are made of highly pure spherical particles. One of the most remarkable properties of every SiliaChrom column is that all types of organic compounds (acidic, basic and neutral) will have optimal peak symmetry with excellent efficiency across the whole applicable pH range. Lot-to-lot reproducibility is ensured by a stable bonding and endcapping process. All columns are packed using a consistent slurry packing process to achieve uniform and stable bed for maximum column efficiency, long lifetime and column-to-column reproducibility.

SiliaChrom HPLC Columns

Main characteristics  > Benefits for the column users
Broad pH range (0,8-12,0) Flexibility for method development
Compatible with 100% aqueous mobile phase Maximum versatility
High surface coverage Tolerance to large volume and mass injected
Minimum buffer concentration needed Better sensitivity for LC-MS and column lifetime
Low bleed High sensitivity for LC-MS
Wide variety of chemistries available Broad selection of polarity
Excellent column effiency Better and faster separation
Long column lifetime Lower cost
Thightest specification Better confidence in HPLC results

 

Standard HPLC Columns

SiliaChrom HPLC columns are available in Narrow Bore, Analytical, Semi-Preparative, and Preparative formats.

SiliaChrom HPLC Standard Column Dimensions
  SiliaChrom HPLC Column Length (mm)
20
30
50
100
150
200
250
Particle Size (µm)
2.5, 3 & 5
2.5, 3 & 5
2.5, 3, 5, 7 & 10
2.5, 3, 5, 7, 10 & 20
2.5, 3, 5, 7, 10 & 20
5 & 10
2.5, 3, 5, 7, 10 & 20
SiliaChrom
HPLC Column
Internal Diameter (mm)
2.0
S
S
S
S
S
C
C
2.1
S
S
S
S
S
C
C
3.0
C
S
S
S
S
C
C
4.6
C
S
S
S
S
S
S
10
C
C
C
S
S
S
S
20
C
C
C
C
S
S
S
30
C
C
C
S
S
S
S
50
C
C
C
S
S
S
S
100
C
C
C
C
C
C
C
  S = Standard C = Custom

 

Distribution

SiliCycle is also an authorized distributor of HPLC columns from other suppliers:

Nacalai Tesque inc.
nacalai tesque inc. - Specialized HPLC Columns Sugar-D, Cholester, HILIC, π-NAP
SIELC Technologies
SIELC Technologies - Mixed Mode Stationary Phases HPLC Columns

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  1. SiliaChrom® Analytical HPLC Columns XDB C18 (H111805H-N100)
  2. SiliaChrom® Semi-Preparative HPLC Columns dt Si

    SiliaChrom® Semi-Preparative HPLC Columns dt Si

    SiliaChrom® dt Si has the same unique technology phase as SiliaChrom AQ Si, but the purity of the spherical silica gel is 99,999%, the highest value for HPLC SiliaChrom Series. This phase has no metal content, in order to avoid secondary interaction with basic or ion species.  

  3. SiliaChrom® Preparative HPLC Columns dt Si

    SiliaChrom® Preparative HPLC Columns dt Si

    SiliaChrom® dt Si has the same unique technology phase as SiliaChrom AQ Si, but the purity of the spherical silica gel is 99,999%, the highest value for HPLC SiliaChrom Series. This phase has no metal content, in order to avoid secondary interaction with basic or ion species.  

  4. SiliaChrom® Narrow Bore HPLC Columns dt Si

    SiliaChrom® Narrow Bore HPLC Columns dt Si

    SiliaChrom® dt Si has the same unique technology phase as SiliaChrom AQ Si, but the purity of the spherical silica gel is 99,999%, the highest value for HPLC SiliaChrom Series. This phase has no metal content, in order to avoid secondary interaction with basic or ion species.  

  5. SiliaChrom® Analytical HPLC Columns dt Si

    SiliaChrom® Analytical HPLC Columns dt Si

    SiliaChrom® dt Si has the same unique technology phase as SiliaChrom AQ Si, but the purity of the spherical silica gel is 99,999%, the highest value for HPLC SiliaChrom Series. This phase has no metal content, in order to avoid secondary interaction with basic or ion species.  

  6. SiliaChrom® Preparative Guard Cartridge XT C18 Fidelity

    SiliaChrom® Preparative Guard Cartridge XT C18 Fidelity

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  7. SiliaChrom® Preparative HPLC Columns XT C18

    SiliaChrom® Preparative HPLC Columns XT C18

    SiliaChrom® XT C18 has a hybrid surface made from a condensation of inorganic SiO2 species and an organosilane (CH3-SiO1.5). This hybrid, a more hydrophobic matrix, presents a very high resistance to extreme high pH conditions (up to 12).

  8. SiliaChrom® Preparative HPLC Columns HILIC

    SiliaChrom® Preparative HPLC Columns HILIC

    SiliaChrom® HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC applications.

  9. SiliaChrom® Preparative Guard Cartridge HILIC

    SiliaChrom® Preparative Guard Cartridge HILIC

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  10. SiliaChrom® Preparative Guard Cartridge dt Si

    SiliaChrom® Preparative Guard Cartridge dt Si

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  11. SiliaChrom® Preparative HPLC Columns dt C18

    SiliaChrom® Preparative HPLC Columns dt C18

    SiliaChrom® dt C18 has the same unique technology phase as SiliaChrom AQ C18, but the purity of the spherical silica gel is 99,999%, the highest value for HPLC SiliaChrom Series. 

  12. SiliaChrom® Preparative Guard Cartridge dt C18

    SiliaChrom® Preparative Guard Cartridge dt C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  13. SiliaChrom® Preparative HPLC Columns XDB2 C18

    SiliaChrom® Preparative HPLC Columns XDB2 C18

    SiliaChrom® XDB2 C18 is grafted on ultrapure spherical silica whose surface was activated to create a high concentration of OH before grafting the C18 function. The residual carbon load is lower than the SiliaChrom XDB1 equivalent.

  14. SiliaChrom® Preparative Guard Cartridge XDB2 C18

    SiliaChrom® Preparative Guard Cartridge XDB2 C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  15. SiliaChrom® Preparative Guard Cartridge SB C8

    SiliaChrom® Preparative Guard Cartridge SB C8

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  16. SiliaChrom® Preparative HPLC Columns SB C18

    SiliaChrom® Preparative HPLC Columns SB C18

    SiliaChrom® SB C18 has the particularity that the silane carries two different functions:

    • The C18 Hydrophobic function

    • Transversal hindered isopropyl groups which protect the surface from an acidic attack.

    This chemistry guarantees the stability of this reverse phase in very low pH (up to 0.8)

  17. SiliaChrom® Preparative Guard Cartridge SB C18

    SiliaChrom® Preparative Guard Cartridge SB C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  18. SiliaChrom® Semi-Preparative HPLC Columns GF-300 AMIDE

    SiliaChrom® Semi-Preparative HPLC Columns GF-300 AMIDE

    This Amide stationary phase, grafted on a silica matrix, is useful for your size exclusion chromatography. SiliaChrom® GF-300 columns present a pore size of 300 Å which permits to separate molecules with a MV between 3 000 and 50 000 Dalton
  19. SiliaChrom® Semi-Preparative HPLC Columns GF AMIDE

    SiliaChrom® Semi-Preparative HPLC Columns GF AMIDE

    This Amide stationary phase, grafted on a silica matrix, is useful for your size exclusion chromatography. SiliaChrom® GF columns present a pore size of 100 Å which permits to separate molecules with a MV less than 3 000 Dalton

  20. SiliaChrom® Semi-Preparative HPLC Columns GF-300

    SiliaChrom® Semi-Preparative HPLC Columns GF-300

    This silica based stationary phase is useful for your size exclusion chromatography. SiliaChrom® GF-300 columns present a pore size of 300 Å which permits to separate molecules with a MV between 3 000 and 50 000 Dalton
  21. SiliaChrom® Semi-Preparative HPLC Columns HILIC-300

    SiliaChrom® Semi-Preparative HPLC Columns HILIC-300

    The chromatographic HILIC function is grafted on a 300 Å pore size spherical silica to separate or purify larger compounds.

  22. SiliaChrom® Semi-Preparative HPLC Columns XDB1 C1-300

    SiliaChrom® Semi-Preparative HPLC Columns XDB1 C1-300

    SiliaChrom® XDB1 C1-300 reverse phase functionalization is completely identical to the XDB1 C1 equivalent. This reverse phase is grafted on a 300 Å pore size spherical silica to separate or purify larger molecules.

  23. SiliaChrom® Semi-Preparative HPLC Columns XDB1 C8-300

    SiliaChrom® Semi-Preparative HPLC Columns XDB1 C8-300

    The SiliaChrom® XDB1 C8-300 reverse phase functionalization is completely identical to the XDB1 C8 equivalent. This reverse phase is grafted on a 300 Å pore size spherical silica to separate or purify larger molecules.

  24. SiliaChrom® Semi-Preparative HPLC Columns XDB1 C18-300

    SiliaChrom® Semi-Preparative HPLC Columns XDB1 C18-300

    SiliaChrom® XDB1 C18-300 reverse phase functionalization is completely identical to the XDB1 C18 equivalent. This reverse phase is grafted on a 300 Å pore size spherical silica to separate or purify larger molecules.

  25. SiliaChrom® Semi-Preparative HPLC Columns SB C8-300

    SiliaChrom® Semi-Preparative HPLC Columns SB C8-300

    SiliaChrom® C8 reverse phase functionalization is completely identical to the SB C8 equivalent. This reverse phase is grafted on a 300 Å pore size spherical silica to separate or purify larger molecules.

  26. SiliaChrom® Semi-Preparative HPLC Columns SB C18-300

    SiliaChrom® Semi-Preparative HPLC Columns SB C18-300

    SiliaChrom® C18 reverse phase functionalization is completely identical to the SB C18 equivalent. This reverse phase is grafted on a 300 Å pore size spherical silica to separate or purify larger molecules.

  27. SiliaChrom® Semi-Preparative HPLC Columns XT C18 Fidelity

    SiliaChrom® Semi-Preparative HPLC Columns XT C18 Fidelity

    SiliaChrom® XT Fidelity C18 has a hybrid surface composed from a condensation of inorganic SiO2 species and an organosilane (CH3-SiO1.5). This hybrid, a more hydrophobic matrix, has an incomparable resistance to extreme high pH conditions (up to 12). The only difference between SiliaChrom XT C18 and SiliaChrom XT Fidelity C18 is the way they are packed, giving Fidelity columns more robustness at high pH and temperature.

  28. SiliaChrom® Semi-Preparative Guard Cartridge XT C18 Fidelity

    SiliaChrom® Semi-Preparative Guard Cartridge XT C18 Fidelity

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  29. SiliaChrom® Semi-Preparative HPLC Columns XT C18

    SiliaChrom® Semi-Preparative HPLC Columns XT C18

    SiliaChrom® XT C18 has a hybrid surface made from a condensation of inorganic SiO2 species and an organosilane (CH3-SiO1.5). This hybrid, a more hydrophobic matrix, presents a very high resistance to extreme high pH conditions (up to 12).

  30. SiliaChrom® Semi-Preparative Guard Cartridge XT C18

    SiliaChrom® Semi-Preparative Guard Cartridge XT C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  31. SiliaChrom® Semi-Preparative HPLC Columns HILIC

    SiliaChrom® Semi-Preparative HPLC Columns HILIC

    SiliaChrom® HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC applications.

  32. SiliaChrom® Semi-Preparative Guard Cartridge HILIC

    SiliaChrom® Semi-Preparative Guard Cartridge HILIC

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  33. SiliaChrom® Semi-Preparative Guard Cartridge dt Si

    SiliaChrom® Semi-Preparative Guard Cartridge dt Si

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  34. SiliaChrom® Semi-Preparative HPLC Columns dt C18

    SiliaChrom® Semi-Preparative HPLC Columns dt C18

    SiliaChrom® dt C18 has the same unique technology phase as SiliaChrom AQ C18, but the purity of the spherical silica gel is 99,999%, the highest value for HPLC SiliaChrom Series. 

  35. SiliaChrom® Semi-Preparative Guard Cartridge dt C18

    SiliaChrom® Semi-Preparative Guard Cartridge dt C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  36. SiliaChrom® Semi-Preparative HPLC Columns XDB2 C18

    SiliaChrom® Semi-Preparative HPLC Columns XDB2 C18

    SiliaChrom® XDB2 C18 is grafted on ultrapure spherical silica whose surface was activated to create a high concentration of OH before grafting the C18 function. The residual carbon load is lower than the SiliaChrom XDB1 equivalent.

  37. SiliaChrom® Semi-Preparative Guard Cartridge XDB2 C18

    SiliaChrom® Semi-Preparative Guard Cartridge XDB2 C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  38. SiliaChrom® Semi-Preparative HPLC Columns XDB1 C8

    SiliaChrom® Semi-Preparative HPLC Columns XDB1 C8

    SiliaChrom® XDB 1 C8 columns offer faster separations for strongly hydrophobic analytes compared to C18 columns. As the C18 XDB1 phase, the C8 XDB1 is highly base deactivated.

  39. SiliaChrom® Semi-Preparative Guard Cartridge XDB1 C8

    SiliaChrom® Semi-Preparative Guard Cartridge XDB1 C8

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  40. SiliaChrom® Semi-Preparative HPLC Columns XDB1 C18

    SiliaChrom® Semi-Preparative HPLC Columns XDB1 C18

    SiliaChrom® XDB1 C18 column has the highest loading density available as well as the highest hydrophobicity. This allows it to have the least interactions between the analytes and potential residual silanol groups.

  41. SiliaChrom® Semi-Preparative Guard Cartridge XDB1

    SiliaChrom® Semi-Preparative Guard Cartridge XDB1

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  42. SiliaChrom® Semi-Preparative HPLC Columns SB C8

    SiliaChrom® Semi-Preparative HPLC Columns SB C8

    SiliaChrom® SB C18 has the particularity that the silane carries two different functions:

    • The C18 Hydrophobic function

    • Transversal hindered isopropyl groups which protect the surface from an acidic attack.

    This chemistry guarantees the stability of this reverse phase in very low pH (up to 0.8)

  43. SiliaChrom® Semi-Preparative Guard Cartridge SB C8

    SiliaChrom® Semi-Preparative Guard Cartridge SB C8

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  44. SiliaChrom® Semi-Preparative HPLC Columns SB C18

    SiliaChrom® Semi-Preparative HPLC Columns SB C18

    SiliaChrom® SB C18 has the particularity that the silane carries two different functions:

    • The C18 Hydrophobic function

    • Transversal hindered isopropyl groups which protect the surface from an acidic attack.

    This chemistry guarantees the stability of this reverse phase in very low pH (up to 0.8)

  45. SiliaChrom® Preparative HPLC Columns XDB1 C18

    SiliaChrom® Preparative HPLC Columns XDB1 C18

    SiliaChrom® XDB1 C18 column has the highest loading density available as well as the highest hydrophobicity. This allows it to have the least interactions between the analytes and potential residual silanol groups.

  46. SiliaChrom® Preparative HPLC Columns SB C8

    SiliaChrom® Preparative HPLC Columns SB C8

    SiliaChrom® SB C18 has the particularity that the silane carries two different functions:

    • The C18 Hydrophobic function

    • Transversal hindered isopropyl groups which protect the surface from an acidic attack.

    This chemistry guarantees the stability of this reverse phase in very low pH (up to 0.8)

  47. SiliaChrom® Preparative HPLC Columns XDB1 C8

    SiliaChrom® Preparative HPLC Columns XDB1 C8

    SiliaChrom® XDB 1 C8 columns offer faster separations for strongly hydrophobic analytes compared to C18 columns. As the C18 XDB1 phase, the C8 XDB1 is highly base deactivated.

  48. SiliaChrom® Semi-Preparative Guard Cartridge SB C18

    SiliaChrom® Semi-Preparative Guard Cartridge SB C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  49. SiliaChrom® Preparative Guard Cartridge XT C18

    SiliaChrom® Preparative Guard Cartridge XT C18

    The SiliaChrom Guard Cartridges increase the shelf life of the SiliaChrom HPLC Columns by retaining impurities before the analytical columns.

  50. SiliaChrom® Semi-Preparative HPLC Columns GF (H900)

    SiliaChrom® Semi-Preparative HPLC Columns GF (H900)

    This silica based stationary phase is useful for your size exclusion chromatography. SiliaChrom® GF columns present a pore size of 100 Å which permits to separate molecules with a MV less than 3 000 Dalton

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