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SiliaChrom®- HILIC HPLC Columns

SiliaChrom HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC application.

siliachrom-hilic logo-sfc-approved

Main Characteristics

  • Unique chemistry (urea)
  • Accepts normal and reversed phases conditions
  • Best replacement for amino HPLC column
  • Provides high efficiency and rapid equilibration
  • Enhanced sensitivity in mass spectrometry
  • Non-endcapped
GENERAL SiliaChrom HILIC CHARACTERISTICS
Columns Pore Size Particle Size Surface Area Carbon Loading
HILIC 100Å 3, 5 µm 410-440 m2/g 8%
Columns pH Range Temperature Limit* Pressure Limit USP Code
HILIC 2,0-8,0 65°C 5000 psi N/A

* At pH range 5 to 7,5

Available column types: Fast analysis, Analytical, Semi-Preparative, Preparative

 

Application Note

Separation of Vitamin B Complex and Vitamin C

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  1. SiliaChrom® Preparative HPLC Columns HILIC

    SiliaChrom® Preparative HPLC Columns HILIC

    SiliaChrom® HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC applications.

  2. SiliaChrom® Semi-Preparative HPLC Columns HILIC-300

    SiliaChrom® Semi-Preparative HPLC Columns HILIC-300

    The chromatographic HILIC function is grafted on a 300 Å pore size spherical silica to separate or purify larger compounds.

  3. SiliaChrom® Semi-Preparative HPLC Columns HILIC

    SiliaChrom® Semi-Preparative HPLC Columns HILIC

    SiliaChrom® HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC applications.

  4. SiliaChrom® Preparative HPLC Columns HILIC-300

    SiliaChrom® Preparative HPLC Columns HILIC-300

    The chromatographic HILIC function is grafted on a 300 Å pore size spherical silica to separate or purify larger compounds.

  5. SiliaChrom® Narrow Bore HPLC Columns HILIC

    SiliaChrom® Narrow Bore HPLC Columns HILIC

    SiliaChrom® HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC applications.

  6. SiliaChrom® Narrow Bore HPLC Columns HILIC-300

    SiliaChrom® Narrow Bore HPLC Columns HILIC-300

    The chromatographic HILIC function is grafted on a 300 Å pore size spherical silica to separate or purify larger compounds.

  7. SiliaChrom® Analytical HPLC Columns HILIC

    SiliaChrom® Analytical HPLC Columns HILIC

    SiliaChrom® HILIC (Hydrophilic Interaction Chromatography) HPLC columns are designed to retain highly polar analytes. SiliaChrom HILIC has a selectivity that is complementary to the one of reversed-phase columns. In fact, it has a higher retention for hydrophilic compounds in HILIC mode. HILIC sorbent is more stable and reproducible than normal phase silica or amino columns. This phase is ideal for MedChem laboratories and approved for SFC applications.

  8. SiliaChrom® Analytical HPLC Columns HILIC-300

    SiliaChrom® Analytical HPLC Columns HILIC-300

    The chromatographic HILIC function is grafted on a 300 Å pore size spherical silica to separate or purify larger compounds.

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