Originally designed by chemists at Bristol-Myers Squibb, the SiliCycle MiniBlock has been further developed to address a wide range of chemistry methodologies. It is a flexible, easy-to-use tool that maximizes the productivity of synthetic chemists.
✓ Solid-Phase Synthesis
✓ Solution-Phase Synthesis
✓ Peptide Synthesis
✓ Parallel Purification
SiliCycle MiniBlock is the only compact parallel synthesizer that allows synthesis via solid or solution-phase as well as purification to be carried out on the same platform. It offers fast bottom filtration without having to invert or disassemble the reactor. Rapid purification and filtration can be achieved by stacking two SiliCycle MiniBlocks and using SPE techniques to remove excess reagents, side-products, catalysts and metals.
Chemists can now take advantage of SiliCycle’s unique expertise in purification, metal scavenging, catalysis and solid-supported reagents in combination with the SiliCycle MiniBlock to increase productivity while reducing development time.
"Since using MiniBlocks, our labs report a 400% increase in new drug candidates and a 40% reduction in development time. MiniBlocks are so widely accepted by our medicinal chemists that 70% of all current programs now use high-throughput chemistry", Dr. Harold Weller, Senior Research Fellow, Bristol-Myers Squibb.
Features and Benefits
One Platform, 6 Configurations
Red and Blue SiliCycle MiniBlock combine to produce 96 compounds.
Continuous inert gas flow enables air/moisture sensitive reactions. Easily add reagents through the septum layer.
Agitation and Resin Washing
Customized shaker allows precision vortex mixing of reactions. Built-in washing capability allows rapid preparation of resins or washing of products while reaction blocks remain on the shaker.
Configure Your SiliCycle MiniBlock to Suit Your Needs
SiliCycle MiniBlock can synthesize compounds in individual vessels ranging in size from as small as 4 mL up to as large as 40 mL, all delivered into racks with microplate footprints. This flexibility provides a smooth, seamless work-flow from synthesis to screening.
With Just the Turn of a Key
Collect products from SiliCycle MiniBlock cleanly and efficiently.
Unique Built-In Valve
Provides rapid bottom filtration – no need to invert or disassemble the reactor. Saves time and prevents cross-contamination.
«Solid-Phase Synthesis of Quinolinone Library»
ACS Comb. Sci. 2015, 17, 60-69
School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea
Department of Medical System Engineering, Institute of Science and Technology, Gwangju, Republic of Korea
Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlocks can be chosen as one of each color (red and blue) or both blocks the same color.
Red/Blue combination is required for collection into a 96-Positions format.
Heating/Cooling Block, allowing uniform cooling to -40°C, and heating to 120°C. Quick to install, efficient condensation. Available in 6, 12, 24 or 48-Positions arrays. Includes quick-disconnect fittings.
Inert gas manifold can be operated in continuous purging or static pressure modes. Internal septum prevents evaporative loss and facilitates reagent addition or reaction sampling. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. For MiniBlock 48-Positions.
For 6,12 and 24-Positions reactors. Provides superior performance for maintaining inert atmosphere while providing a cost effective option for evaporating solvents. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. Includes one box of sealing layer and one box of Inner/Piercing septa.