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SiliaQuick QuEChERS for Analytical Toxicology and Drug Testing

SiliaQuick QuEChERS for Analytical Toxicology and Drug Testing

In analytical toxicology and drug testing, the extraction step is critical as it aims at a double objective: extract your compound of interest efficiently and clean-up the extract while avoiding degradation of sensitive analytes.

Processes consisting in a liquid-liquid extraction and off-line SPE are often efficient, but LLE are difficult to automate, require large volumes of solvents (including halogenated ones), are emulsion-prone, whereas SPE are complex and difficult to master, ineffective toward many analytes, and very lengthy to develop (necessitate time and efforts). Proteins precipitations with methanol or acetonitrile are quicker but dedicated to whole blood or plasma-serum matrices.

New to SiliaQuick ? Read SiliaQuick QuEChERS introduction

Because of their easiness, low cost and efficiency, QuEChERS, initially dedicated to pesticides are booming in the area of biological and forensic toxicological applications.

This approach was successfully applied to the development of several detection and quantifications methods which have now become classics:

  • antiepileptics,
  • anticoagulants,
  • androgens,
  • blood doping compounds,
  • peptide hormones,
  • stimulants,
  • diuretics,
  • narcotics,
  • ivabradine,
  • ...

 

New applications are rising and include emerging drugs of abuse such as synthetic cannabinoids ("spice drugs"), recreational designer drugs ("bath salts"), prescription drugs and so on...

SiliaQuick QuEChERS for detection of spice drugs SiliaQuick QuEChERS for detection of recreational designer drugs SiliaQuick QuEChERS for detection of prescription drugs

 

In forensic toxicological analysis, most frequent matrices include plasma, serum, whole blood and urine, but liver is commonly used as an alternative biological specimen in cases in which blood and urine cannot be obtained.
Additionally, the use of hair, saliva, feces, meconium and tears are strongly increasing.
Detection limits usually range from ng/mL to pg/mL, but can even reach the fg/mL !

SiliaQuick QuEChERS for forensics analysis SiliaQuick QuEChERS for plasma, serum and blood analysis SiliaQuick QuEChERS for urine analysis

Many applications in forensic toxicology have been successfully evaluated according to various ISO standards, including the ISO 17025 standard.

 

Choose the right SiliaQuick kit for your matrice:

Blood:

  • SiliaQuick Pigmented Fruits & Vegetable kit
  • SiliaQuick Fatty and Waxed Fruits & Vegetables kit

Urine:

  • SiliaQuick General Fruits & Vegetable kit
  • SiliaQuick Fatty and Waxed Fruits & Vegetables kit

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  1. SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 15 mL tube

    SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 15 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, EN 15662 method, for fatty and waxed fruits & vegetables. 15mL format.
  2. SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 15 mL tube

    SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 15 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, AOAC 2007.01 method, for fatty and waxed fruits & vegetables. 15mL format.
  3. SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 2 mL tube

    SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 2 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, EN 15662 method, for fatty and waxed fruits & vegetables. 2mL format.
  4. SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 2 mL tube

    SiliaQuick™ QuEChERS for Fatty & Waxed Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 2 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, AOAC 2007.01 method, for highly fatty and waxed fruits & vegetables. 2mL format.
  5. SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 15 mL tube

    SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 15 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, EN 15662 method, for pigmented fruits & vegetables. 15mL format.
  6. SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 15 mL tube

    SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 15 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, AOAC 2007.01 method, for pigmented fruits & vegetables. 15mL format.
  7. SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 2 mL tube

    SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 2 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, EN 15662 method, for pigmented fruits & vegetables. mL format.
  8. SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 2 mL tube

    SiliaQuick™ QuEChERS for Pigmented Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 2 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, AOAC 2007.01 method, for pigmented fruits & vegetables. 2mL format.
  9. SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 15 mL tube

    SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 15 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, EN 15662 method, for general fruits & vegetables.15mL format.
  10. SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 15 mL tube

    SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 15 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, AOAC 2007.01 method, for general fruits & vegetables. 15mL format.
  11. SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 2 mL tube

    SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for EN 15662, 2 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, EN 15662 method, for general fruits & vegetables. 2mL format.
  12. SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 2 mL tube

    SiliaQuick™ QuEChERS for General Fruits & Vegetables Dispersive SPE Clean-up Kit for AOAC 2007.01, 2 mL tube

    Dispersive cleaning kit for the SiliaQuick™ QuEChERS, AOAC 2007.01 method,for general fruits & vegetables. 2mL format.

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