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SiliaBond® Carbonate

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SiliaBond® Carbonate

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Product Number Quantity  
R66030B-5g 5 g

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R66030B-10g 10 g

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R66030B-25g 25 g

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R66030B-50g 50 g

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R66030B-100g 100 g

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R66030B-250g 250 g

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R66030B-500g 500 g

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R66030B-1kg 1 kg

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Product Description

Specifications


 
  • Details

    SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

    SiliaBond Carbonate is also very efficient at scavenging boronic acids: 99% removal of phenylboronic acid with one equivalent in DCM at room temperature after 1h. Si-CO3 can free base ephedrine hydrochloride quantitatively (100% yield determined by 1H NMR) using 4 equivalents at room temperature for two hours.

    PRODUCT SPECIFICATIONS

    MSDS-R66030B

    APPLICATION NOTES
    Amide & Ester Synthesis : Amine Free Basing 1
    Scavengers : Scavenging HOBt 2 and TFA Removal

    POSTERS
    Click here to see all the documentation about SiliaBond®

    RELATED PUBLICATIONS

    1. Org. Lett., 4 (2002) 1167
    2. Org. Lett., 5 (2003) 4721
    3. J. Comb. Chem., 9 (2007) 677
    4. J. Comb. Chem., 10 (2008) 235
    5. Bioorg. Med. Chem. Lett., 20 (2010), 232
  • Additional Information

    Array CHIRAL Amylose T-DPC
    Family / Formats SiliaBond® (Functionalized Silicas)
    Particle Size 40-63 µm / 230-400 mesh
    Pore Size 60 Å
    Endcapping Endcapped
    Storage Condition Keep dry