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5. Scavenging Pd(Dppf)Cl2 Catalyst

Pd(dppf)Cl2 is a new catalyst becoming more and more popular in palladium-catalyzed cross-coupling reaction like Suzuki coupling. This catalyst offers non-negligeable advantages compared to tetrakis(triphenylphosphine)-palladium(0) [Pd(PPh3)4]: more stable, less air-sensitive, and longer shelf-life.

A metal scavenging study using SiliaBond® Metal Scavengers products was conducted on Pd(dppf)Cl2 catalyst. Various parameters were studied for their influence on the scavengers' robustness as well as to establish the best conditions to bring the level of metal down to an acceptable level for the pharmaceutical industry (i.e.: solvent, number of equivalents, temperature, and reaction time).

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