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Reductive Amination - Use Of SiliaBond® Cyanoborohydride

SiliaBond® Cyanoborohydride is the silica bound equivalent of sodium cyanoborohydride. It is very useful in reductive amination and in the reduction of imines. Cyanide contamination of the product is a concern when using the solution phase equivalent. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica. Additionally, it may be used to reduce α, β-unsaturated carbonyls to the corresponding unsaturated alcohols.

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