Frequently Asked Questions about Metal & Organic Scavengers
Here you will find questions and answers about our metal scavengers (SiliaMetS) and organic scavengers (SiliaBond), in their various applications and formats (bulk or packaged as E-PAK Cartridges).
If you still have questions, please contact our technical support department: [email protected].
Scavengers Overview
◼ What are metal scavengers?
◼ What is a supported scavenger?
◼ What are the advantages of choosing a silica-based product over a polymer-based one?
◼ What is the shelf life of SiliaMetS and can it be used once the shelf life expired?
◼ Can I use your scavengers in flow type applications?
◼ Can Potentially Genotoxic Impurities (PGI) be removed by SiliaMetS metal scavengers and/or SiliaBond organic scavengers?
◼ Do SiliaMetS scavengers leach?
◼ Does SiliCycle have a solution to freebase amines from their TFA salt form?
◼ Do you have customers in the pharma industry who have already used SiliaMetS?
Scavengers Availability
◼ Are the scavengers available at metric ton quantities?
◼ What other formats are your scavengers available in?
◼ Are you a distributor or a manufacturer of scavengers?
◼ How do you maintain batch-to-batch product quality?
Scavengers Selection
◼ How to choose a scavenger?
◼ Why are screening tests important regarding the selection of a metal scavenger?
◼ How much and how long is the screening service?
Scavengers Preparation
◼ What is molecular loading and how do you determine the molecular loading of a SiliaMetS metal scavenger?
◼ How do you calculate how much scavenger to use?
◼ I have a significant quantity of metal to be removed from my mixture, will the 4-8 equivalents of SiliaMetS recommended for a typical initial screening suffice?
◼ What are the densities of the SiliaBond organic scavengers & SiliaMetS metal scavengers?
◼ Do SiliaMetS require an activation step prior to their use?
Use of Scavengers
◼ Can I just dump your scavenger into a reactor?
◼ What kind of solvent would be preferred with SiliaMetS and SiliaBond scavengers?
◼ What is the scavenging reaction time?
◼ At what temperature should scavengers be used?
◼ What is the thermal stability of SiliaMetS Thiol?
◼ What is the mechanical stability of SiliaMetS metal scavengers?
◼ At what pH should the scavenging in aqueous solution be performed?
◼ What will happen to my scavenger if I do not work in the recommended pH scale (between 2 and 10)?
Post-Scavenging
◼ Can the metal scavenged be recovered?
◼ How do you clean the reactors after using scavengers?
◼ How should I test my reactor to determine if I removed all of your scavenger?
Scavengers Documentation & Regulatory Aspects
◼ What documents are routinely provided to customers?
◼ Do you provide an SOP for used scavengers?
◼ Can SiliCycle help with regulatory support?
E-PAK Cartridges for flow-through scavenging
◼ What are the different E-PAK cartridge sizes available and what are the typical pressure and flow rate for each one?
◼ Can we recirculate a solution several times in an E-PAK cartridge or is it single pass only?
◼ What are the maximum pressure and temperature at which the E-PAK can operate?
◼ What is the recommended pH range when using the E-PAK cartridges?
◼ What is the chemical compatibility of the E-PAK cartridges?
◼ Do you provide a Certificate of Analysis (CoA) for the E-PAK cartridges?
◼ How to select the appropriate E-PAK cartridge size?
◼ Which carbon should I select for my purification?
◼ What is the housing material?
◼ What inlet and outlet fittings are required for the housings?
◼ What is the pressure rating for the housing?
◼ What is the temperature rating required for the housing?
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Choosing your metal & organic scavenging solution
Poster - Helps to choose among SiliCycle's unparalleled range of Metal and Organic Scavengers, SiliaMetS® and SiliaBond®. -
Solutions for Scavenging of Metal and Organic Impurities (BROSCA)
Brochure, 28 pages. Product lines: SiliaMetS Metal Scavengers, SiliaBond Organic Scavengers and E-PAK Fixed Bed Flow Purification Cartridges