How to purify your API from organic contaminants?

> back to the scavengers FAQ page

Two Ways SiliaBond Organic Scavengers can help you purify your API from organic contaminants

Method 1: Direct scavenging of the undesired compound to isolate the API

• Silica is bound with a functional group, that will specifically react with a product : either excess reagents (unreacted) or impurities.
• The API is recovered by simple filtration as demonstrated on the following scheme:

Method 2: Catch and release of the API

SiliaBond scavenger is packed in a SPE cartridge:

• Conditioning step: with six to ten hold-up volumes of solvent
• Loading step: API is loaded and trapped onto the cartridge bed
• Washing step: cartridge is washed to filter excess reagents and / or other impurities
• Elution step: API is eluted, recovered and purified

Learn more:

• SiliaBond Organic Scavengers
• Catch and Release technique