What kind of solvent would be preferred with SiliaMetS?

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SiliaMetS scavengers can safely be used in a wide range of organic and aqueous solvents commonly used in laboratory and in process, such as DMF, DMSO, THF, 2-butanone, alcohols, ethers, chlorinated solvent, etc. Exceptions are Si-Cysteine, Si-Amine, Si-Diamine and Si-Triamine which should not be used under aqueous conditions. Moreover, some are solely compatible with aprotic solvents (Si-Carbonate, Si-Isocyanate and Si-Tosyl Chloride (which is also unstable in DMF)). Finally, Si-Maleimide should only be used in polar solvents (DMF, MeOH, H₂O, etc.).

As demonstrated in the graph below, the nature of the solvent can sometimes influence the scavenging efficiency. In fact, if scavenging or kinetics are too slow, changing the solvent or adding a co-solvent should be considered.