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SiliaBond Ion Exchangers

> back to SiliaBond chromatographic phases

In ion exchange chromatography, both silica support and analytes must be ionized.

  • If the stationary phase (packing material) is positively charged, anionic analytes only will retain (these phases are called WAX & SAX).
  • And in the contrary if the stationary phase is negatively charged, cationic analytes only will retain (these phases are called WCX & SCX).

Hence, pH of the mobile phase is of crucial importance and needs to be chosen carefully, so that both functions are charged:

SiliaBond Ion Exchange Chromatographic Phases and pH

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  1. SiliaBond Amine (WAX) nec (R52130B)

    SiliaBond Amine (WAX) nec (R52130B)

    SiliaBond Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
  2. SiliaBond Amine (WAX) (R52030B)

    SiliaBond Amine (WAX) (R52030B)

    SiliaBond Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
  3. SiliaBond Triethylamine (TEA) (R76530B)

    SiliaBond Triethylamine (TEA) (R76530B)

    SiliaBond Triethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. SiliaBond Triethylamine is also used as weak anion exchanger (WAX) in SPE.
  4. SiliaBond TMA Chloride (SAX) nec (R66530B)

    SiliaBond TMA Chloride (SAX) nec (R66530B)

    SiliaBond TMA Chloride (SiliaBond SAX, Si-TMACl) is mainly used as strong anion exchanger (SAX) in ion chromatography and ion exchange SPE. The function bears a positive charge across the whole pH range as well as in organic solvents.

  5. SiliaBond TMA Chloride (SAX)

    SiliaBond TMA Chloride (SAX) (R66630B)

    SiliaBond TMA Chloride (SiliaBond SAX, Si-TMACl) is mainly used as strong anion exchanger (SAX) in ion chromatography and ion exchange SPE. The function bears a positive charge across the whole pH range as well as in organic solvents. It is especially used for the “Catch and Release” purification of weak acids.
  6. SiliaBond TMA Acetate (SAX-2) nec (R66430B)

    SiliaBond TMA Acetate (SAX-2) nec (R66430B)

    Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate.
  7. SiliaBond Tosic Acid nec (SCX) scavenger (R60430B)

    SiliaBond Tosic Acid nec (SCX) (R60430B)

    SiliaBond Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1, widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
  8. SiliaBond Tosic Acid (SCX) scavenger (R60530B)

    SiliaBond Tosic Acid (SCX) (R60530B)

    SiliaBond Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
  9. SiliaBond Propylsulfonic Acid (SCX-2) (R51230B)

    SiliaBond Propylsulfonic Acid (SCX-2) (R51230B)

    Strong acid widely used in different fields of synthetic organic chemistry. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. The most common use is probably as a strong cation exchanger (SCX) for the amine "Catch and Release" purification technique in SPE cartridges.
  10. SiliaBond Propylsulfonic Acid nec (SCX-2) (R51430B)

    SiliaBond Propylsulfonic Acid nec (SCX-2) (R51430B)

    Strong acid widely used in different fields of synthetic organic chemistry. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. The most common use is probably as a strong cation exchanger (SCX) for the amine "Catch and Release" purification technique in SPE cartridges.
  11. SiliaBond Carboxylic Acid (WCX) (R70030B)

    SiliaBond Carboxylic Acid (WCX) (R70030B)

    SiliaBond Carboxylic Acid (Si-CAA) can be used as a scavenger for amines or carbonates, and for the quench of alkoxides and organometallic reagents. SiliaBond Carboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC.

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