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SiliaBond for Alkylation & Etherification Reactions

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Alkylation reactions are the transfer of an alkyl group from one molecule to the other via alkylating agents, that may have an electrophilic or nucleophilic character. Etherifications are a type of C-O bond formation reaction, usually from the SN2 reaction between an organohalide and an alcohol.

Just like for acylation reactions, the most common type of alkylation is the Friedel-Crafts reaction and the typical etherification reaction is the Williamson synthesis.

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  1. SiliaBond Aluminum Chloride (AlCl3) (R74530B)

    SiliaBond Aluminum Chloride (AlCl3) (R74530B)

    SiliaBond® Aluminium Chloride (Si-AlCl3) is the silica supported version of the most widely used Lewis acid, aluminium chloride. It is an effective catalyst for Friedel-Crafts alkylations and acylations. It also catalyzes the formation of ethers.
  2. SiliaBond Guanidine (GUA) (R68230B)

    SiliaBond Guanidine (GUA) (R68230B)

    SiliaBond Guanidine is a silica-supported diisopropylguanidine ligand. It is a very powerful scavenger for the chelating of organic acids in general, especially boronic acids and phenolic acids. It may also be used as a very strong base. It is sufficiently basic to deprotonate moderately acidic hydrogens, as in the alkylation of amines and phenols (Williamson ether synthesis) and the esterification of carboxylic acids using alkyl halides.

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