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SiliaBond for Nitro-Aldol (or Henry) Reactions

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The Henry reaction is commonly used to form carbon-carbon bonds by addition of nitroalkanes over aldehydes. This reaction is a useful technique in organic chemistry due to the synthetic utility of its corresponding products, as they can be easily converted to other useful synthetic intermediates such as nitroalkenes by dehydrogenation, α-nitro ketones by oxidation and β-amino alcohols by reduction.
Usually, the Henry reaction is carried out in presence of bases in homogeneous solution, giving low yield due to side reactions such as retroaldol and Cannizarro reactions.

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  1. SiliaBond Piperazine (R60030B)

    SiliaBond Piperazine (R60030B)

    SiliaBond Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc1 and Bsmoc2 amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.
  2. SiliaBond Carbonate (CO3) (R66030B)

    SiliaBond Carbonate (CO3) (R66030B)

    SiliaBond Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

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