SiliaBond® Pyridinium Chlorochromate (Si-PCC) is used for the general oxidation of alcohols to carbonyl compounds, selective oxidation of allylic and benzylic alcohols, organometallic oxidation, oxidative transpositions, oxidative cleavages, allylic and benzylic oxidation and oxidative cyclizations.1-4
Using PCC immobilized onto silica gel provides anhydrous conditions that may otherwise promote side reactions and reduce yields. It greatly facilitates removal of polymeric reduced chromium by-products and is compatible with acid-sensitive protecting groups.5,6 When used in conjunction with ultrasounds, kinetics are increased and the amount of oxidant required to complete the reaction is decreased.7-9
Oxidation of 4-tert-butylcyclohexanol to 4-tert-butylcyclohexanone with 2 eq. in anhydrous DCM at room temperature is complete after 6 hours.
PRODUCT SPECIFICATIONS
MSDS-R24030B
APPLICATION NOTE
Oxidation of Alcohols
RELATED PUBLICATIONS
- J. Org. Chem., 54 (1989) 5387
- Tetrahedron Lett., 42 (2001) 2141
- Synlett, 10 (1999) 1630
- Synth. Commun., 26 (1996) 225
- J. Org. Chem., 58 (1993) 2509
- J. Chem. Educ., 76 (1999) 974
- J. Org. Chem., 48 (1983) 666
- Liebigs Ann. Chem., (1993) 173
- J. Org. Chem., 57 (1992) 3867