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SiliaBond for Reductive Amination
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Reductive amination involves the conversion of a carbonyl group, most of the time a ketone or an aldehyde, to an amine via an intermediate imine or iminium. The intermediate imine is reduced by sodium cyanoborohydride.
This is known as direct reductive amination and is carried out with reducing agents that are more reactive toward protonated imines (or iminiums) than ketones and are stable under moderately acidic conditions.
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SiliaBond Cyanoborohydride (CBH) (R66730B)
SiliaBond® Cyanoborohydride (Si-CBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica.
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