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SiliaBond Acids, Bases & Others

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Acids

Best SiliaBond Acids Typical Reactions & Applications Examples
SiliaBond Carboxylic Acid
  • Nucleophilic acyl substitutions: esters hydrolysis, Fisher esterifications, amides hydrolysis, etc.
  • A chromatographic phase week cation exchanger at pH ≥ 6.8 that can be eluted at a pH ≤ 2.8
SiliaBond Propylsulfonic Acid
  • Nucleophilic acyl substitutions such as transesterifications, etc.
  • Carbon-carbon coupling reactions
SiliaBond Tosic Acid
  • A chromatographic phase strong cation exchanger that is permenently negatively charged (pKa < 1)
  • Ionic scavenging
  • Deprotections of aromatic ethers
  • Fries rearrangements

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Bases

Best SiliaBond Bases Typical Reactions & Applications Examples
SiliaBond Amine
  • Organic scavenging of electrophiles
  • Ionic scavenging
  • Nucleophilic-catalyzed reactions
  • Acid-catalyzed reactions: Aldol reactions, Retro-Claisen reaction, Mannich reactions...
SiliaBond Carbonate
  • Ionic scavenging
  • Nitro-Aldol (Henry) reactions & Michael additions
  • Amine free-basing
  • Compatible with solvent-free conditions
SiliaBond Dimethylamine
  • Knoevenagel condensations
  • Catch andd release purification of compounds bearing a permanent negative charge such as salts of sulfonic acids
SiliaBond Guanidine
  • Alkylations
  • Strecker-type reactions
  • Etherifications such as Williamson synthesis
  • Michael additions and more generally speaking 1,4 addition reactions
  • Ionic scavenging
  • Deprotonates moderately acidic hydrogens
SiliaBond Morpholine
  • Acid sponge
  • Enamine formations
  • Mannich condensations
  • Less nucleophilic and less basic than piperidine hence forming stable chloramines
SiliaBond Piperazine
  • Deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups
  • Knoevenagel condensations
  • Ionic & nucleophile scavenger
SiliaBond Piperidine
  • Deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups
  • Knoevenagel condensations
  • Ketones to enamines conversions
  • Production of dipiperidinyl dithiuram tetrasulfide (rubber vulcanization accelerator)

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Linkers

Synthesis of homemade functionalized silicas according to your very own application

SiliaBond Typical Reactions & Applications Examples
SiliaBond Allyl
  • Allylic oxidations
  • Ene reactions
  • Tsuji-Trost reactions
  • Rancidification
SiliaBond Bromophenyl
  • Introduction of phenyl groups via Pd-catalyzed couplings
  • Synthesis of Grignard reagents
SiliaBond Glycidoxy
  • Immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups
  • Ring-opening reactions & hydrolysis
  • Reduction with tungsten hexachloride
  • Reduction with lithium aluminum hydride
SiliaBond Phenylmethylchloride
  • Nucleophilic substitutions for introduction of phenyl linker
SiliaBond Propyl Bromide
  • Nucleophilic substitutions for introduction of n-propyl linker

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