SiliaBond Acids, Bases & Others
> back to SiliaBond Acids, Bases & Others
Acids
| Best SiliaBond Acids |
Typical Reactions & Applications Examples |
| SiliaBond Carboxylic Acid |
- Nucleophilic acyl substitutions: esters hydrolysis, Fisher esterifications, amides hydrolysis, etc.
- A chromatographic phase week cation exchanger at pH ≥ 6.8 that can be eluted at a pH ≤ 2.8
|
| SiliaBond Propylsulfonic Acid |
- Nucleophilic acyl substitutions such as transesterifications, etc.
- Carbon-carbon coupling reactions
|
| SiliaBond Tosic Acid |
- A chromatographic phase strong cation exchanger that is permenently negatively charged (pKa < 1)
- Ionic scavenging
- Deprotections of aromatic ethers
- Fries rearrangements
|
> all SiliaBond Acids
Bases
| Best SiliaBond Bases |
Typical Reactions & Applications Examples |
| SiliaBond Amine |
- Organic scavenging of electrophiles
- Ionic scavenging
- Nucleophilic-catalyzed reactions
- Acid-catalyzed reactions: Aldol reactions, Retro-Claisen reaction, Mannich reactions...
|
| SiliaBond Carbonate |
- Ionic scavenging
- Nitro-Aldol (Henry) reactions & Michael additions
- Amine free-basing
- Compatible with solvent-free conditions
|
| SiliaBond Dimethylamine |
- Knoevenagel condensations
- Catch andd release purification of compounds bearing a permanent negative charge such as salts of sulfonic acids
|
| SiliaBond Guanidine |
- Alkylations
- Strecker-type reactions
- Etherifications such as Williamson synthesis
- Michael additions and more generally speaking 1,4 addition reactions
- Ionic scavenging
- Deprotonates moderately acidic hydrogens
|
| SiliaBond Morpholine |
- Acid sponge
- Enamine formations
- Mannich condensations
- Less nucleophilic and less basic than piperidine hence forming stable chloramines
|
| SiliaBond Piperazine |
- Deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups
- Knoevenagel condensations
- Ionic & nucleophile scavenger
|
| SiliaBond Piperidine |
- Deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups
- Knoevenagel condensations
- Ketones to enamines conversions
- Production of dipiperidinyl dithiuram tetrasulfide (rubber vulcanization accelerator)
|
> all SiliaBond Bases
Linkers
Synthesis of homemade functionalized silicas according to your very own application
| SiliaBond |
Typical Reactions & Applications Examples |
| SiliaBond Allyl |
- Allylic oxidations
- Ene reactions
- Tsuji-Trost reactions
- Rancidification
|
| SiliaBond Bromophenyl |
- Introduction of phenyl groups via Pd-catalyzed couplings
- Synthesis of Grignard reagents
|
| SiliaBond Glycidoxy |
- Immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups
- Ring-opening reactions & hydrolysis
- Reduction with tungsten hexachloride
- Reduction with lithium aluminum hydride
|
| SiliaBond Phenylmethylchloride |
- Nucleophilic substitutions for introduction of phenyl linker
|
| SiliaBond Propyl Bromide |
- Nucleophilic substitutions for introduction of n-propyl linker
|
> all SiliaBond Linkers
> back to SiliaBond Acids, Bases & Others
