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SiliaBond Genotoxic Impurities Scavengers

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Potential Genotoxic Impurities (PGI) compounds cause DNA damage by various mechanisms such as alkylation or other interactions and lead to mutation of the genetic code. They have gained considerable attention due to their carcinogenic character to induce genetic mutations and / or chromosomal rearrangements.

In situations where formation of PGIs cannot be avoided, an ideal solution would be to perform complete removal of PGIs after the synthesis is completed.
For example, recrystallization, preparative chromatography or other downstream processing approaches might be considered. Many disadvantages of using such approaches include: potential yield loss, high solvent consumption, additional time and resources required for process development.

Our line of SiliaBond Organic Scavengers will help you remove PGIs from you chemistry.

> contact us to learn more about PGI scavenging: scavengers@silicycle.com

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  1. SiliaBond Piperazine (R60030B)

    SiliaBond Piperazine (PPZ) (R60030B)

    SiliaBond Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.
  2. SiliaBond Piperidine (PIP) (R71530B)

    SiliaBond Piperidine (PIP) (R71530B)

    SiliaBond Piperidine (Si-PIP) is a general purpose tertiary amine base to scavenge acids, thereby avoiding salt elimination problems. Also used as a base catalyst for Knoevenagel condensation.
  3. SiliaMetS Triamine metal scavenger (R48030B)

    SiliaMetS Triamine (R48030B)

    Effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
  4. SiliaMetS Diamine (R49030B)

    SiliaMetS Diamine (R49030B)

    SiliaMetS is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates. Best metal scavenger for: Cr, Pd, Pt, W & Zn. Good scavenger for: Cd, Co, Cu, Fe, Hg, Ni, Pb, Ru, Sc, Se & V.
  5. SiliaMetS Thiol (SH) (R51030B)

    SiliaMetS Thiol (SH) Metal Scavenger (R51030B)

    Our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions. Best scavenger for: Ag, Hg, Os, Pd & Ru. Good scavenger for: Cu, Ir, Pb, Rh, Se & Sn.
  6. SiliaMetS DMT (Dimercaptotriazine) (R79030B)

    SiliaMetS DMT (Dimercaptotriazine) (R79030B)

    SiliaMetS DMT is the silica - bound equivalent of 2,4,6 - trimercaptotriazine (trithiocyanuric acid, TMT). It is a versatile metal scavenger for a variety of metals and the preferred metal scavenger for ruthenium catalysts and hindered Pd complexes. Best scavenger for: As, Ir, Ni, Os, Pd, Pt, Rh, Ru & Se. Good scavenger for: Cd, Co, Cu, Fe, Sc & Zn.

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