An AstraZeneca Case Study
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In 2008, AstraZeneca published a paper in witch they removed palladium impurities in a large-scale process. The workup method that was found to work the best was a treatment with SiliaMetS Thiol (25 % w/w or ~1.4 kg) at 50°C to purify more than 6.7 kg. Final residual palladium concentration was as low as 1-2 ppm
Process Chemistry, AstraZeneca PR&D, Sweden.
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SiliaMetS Thiol (SH) Metal Scavenger (R51030B)
Our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions. Best scavenger for: Ag, Hg, Os, Pd & Ru. Good scavenger for: Cu, Ir, Pb, Rh, Se & Sn.
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