Synthesis of a Multivalent Glycoligand against Avian and Human Influenza Viruses

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A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition.

The prepared glycopolymer with pendant 3’-sialyllactose moieties strongly interacted with both avian & human influenza viruses.

SiliaMetS Imidazole was successful in removing contaminating Cu, with only 5 equiv., O.N. at r.t. (see scheme below).

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• An α2,3-Linked Sialylglycopolymer as a Multivalent Glycoligand against Avian and Human Influenza Viruses (PDF)
• SiliaMetS Imidazole
• SiliaMetS Metal Scavengers