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SiliaMetS DEAM (R54430B)

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SiliaMetS DEAM (R54430B)

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Product Number Quantity  
R54430B-5G 5 g

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R54430B-10G 10 g

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R54430B-25G 25 g

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R54430B-50G 50 g

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R54430B-100G 100 g

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R54430B-250G 250 g

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R54430B-500G 500 g

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R54430B-1KG 1 kg

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Product Description

Specifications

Documentations


 
  • Details

    SiliaMetS DEAM:  Your last step toward uncompromised purity
    Effectively eliminates trace metals and boronic acids from products

    SiliaMetS DEAM is a versatile scavenger designed to remove trace metal or boronic acids from reaction intermediates or final APIs. 

    Metals Removed

    • Best scavenger for: Ag, Fe, Sn, Ti & Zn.
    • Good scavenger for: Se.

    Scavengers are our class of functionalized silica that exhibit ability to bond (that is, to “scavenge”) various metal compounds or organic molecules dissolve in solution. In organic chemistry, formation of new bonds is of utmost importance and for this to be achieved, cross-coupling reactions are among the most important processes.
    Initially these reactions used simple Pd-catalysts. However, the need to carry out more challenging coupling reactions has resulted in the development of more advanced catalysts and the use of many different metals.

    Our SiliaMetS DEAM is your best choice for the scavenging of Titanium (Ti), and is also very powerful for Zinc (Zn), Iron (Fe) and Silver (Ag). Apart from the pharmaceutical industry, metal scavengers such as DEAM can be used in many other industries that need to recover low levels of precious metals, such as mining, refining, manufacturing, etc.

    SiliaMetS DEAM is a very versatile scavenger, as it is dual-purpose:  it also is a highly effective tool to remove excess boronic acids from non-aqueous solutions. Boronic acids are widely used in organic synthesis and for a vast range of biological, medicinal and synthetic applications, particularly Suzuki coupling reactions.

    Our SiliaMetS DEAM is the first DEAM-silica supported on the market, and is produced in large scale in our state-of-the-art facilities.

     

    Scheme 1. Scavenging of a boronic acid using Si-DEAM

    Table 1

    Scavenging activity for metals by SiliaMetS DEAM
    Complex Metal Solvent Scavenging Efficiency
    Pd(OAc)2 Pd DMF 74 %
    Zn(OAc)2 Zn DMF 96 %
    FeCl3.6H2O Fe DMF 96 %
    Ti(OiPr)4 Ti DMF 92 %
    AgNO3 Ag DMF 88 %

    Table 2

    Scavenging activity for phenyl boronic acid by SiliaMetS DEAM for 1h at room temperature
    Nb of eq. Scavenging Efficiency
    1
    2

    Table 3

    Typical Reaction Applications for SiliaMetS DEAM in order to remove catalyst
    Reaction Catalyst to be scavenged
    Suzuki coupling boronic acid
    Lewis Acids TiCl4 & alkoxide derivatives
    Sakuraï reaction TiCl4
    Mukayama-Aldol reation
    Knoevenagel condensation
    Reductive alkylation of 1st to 2nd amines TIPP
    Reductive amination of enolizable carbonyls
  • Additional Information

    Array DEAM
    Family / Formats SiliaMetS® (Metal Scavengers)
    Particle Size 40 - 63 µm / 230 - 400 mesh
    Pore Size 60 Å
    Endcapping Endcapped
    Storage Condition Keep dry under Argon
    Solvent Compatibility All organic solvents
    Typical Tap Density 679 g/L
    Molecular Loading 0.85 mmol/g
    Color Off-white
  • Documentations