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A Johnson & Johnson Case Study

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In 2009, J&J in collaboration with Solvias published a paper in witch they developed a mild Sonogashira reaction using various metal catalysts. Treatment with SiliaMetS Thiol removed simultanously Pd, Cu & Al. Residual concentrations were respectively < 50, 10, and 3 ppm, in the isolated product 3. Take a look at J&J’s publication for more details.

Note: copper comes from a previous synthesis step.

case-study-johnson-johnson

Houpis I.N. & all, Organic Process Research & Development, 2009, 13, 598
Johnson & Johnson PRD, API Development, Belgium, and Solvias A.G., Synthesis and Catalysis, Switzerland.

 

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  1. SiliaMetS Thiol (SH) (R51030B)

    SiliaMetS Thiol (SH) (R51030B)

    Our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions. Best scavenger for: Ag, Hg, Os, Pd & Ru. Good scavenger for: Cu, Ir, Pb, Rh, Se & Sn.

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