Follow SiliCycle on Facebook Follow SiliCycle on Twitter Follow SiliCycle on LinkedIn Watch our videos on Youtube

Discovery and Synthesis of a Direct Activator of AMP-Kinase PF-06409577 against Diabetic Nephropathy

> back to SiliaMetS Case Studies

Adenosine monophosphate-activated protein kinase (AMPK) is a protein kinase involved in maintaining energy homeostasis within cells. PF-06409577 has been discovered as an indole acid with excellent balance of properties and has now been advanced to first-in-human trials for the treatment of diabetic nephropathy. Key indazoles in the synthesis were prepared by Suzuki coupling to some commercially available 5-bromoindazoles (scheme).

SiliaMetS Thiol was used to remove remaining Pd after only 30 min of stirring.

Cameron, K. et al. J. Med. Chem., 2016, 59, 8068 - 8081

 

Read more

1 Item(s)

Set Descending Direction
per page

List  Grid 

  1. SiliaMetS Thiol (SH) (R51030B)

    SiliaMetS Thiol (SH) (R51030B)

    Our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions.

1 Item(s)

Set Descending Direction
per page

List  Grid