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Multiple Metal Scavenging with SiliaMetS

SiliaMetS can be used to remove multiple metals in the same reaction with excellent efficiency. The Negishi coupling presented below was performed and SiliaMetS was used to remove simultaneously residual zinc, palladium and iron present after the reaction.

negishi-coupling

Multiple Removal Scavenging Results
SiliaMetS Palladium Iron Zinc
SiliaMetS Cysteine 95 % > 99 % 98 %
SiliaMetS DMT 83 % 93 % 99 %
SiliaMetS Imidazole 84 % 91 % 97 %
SiliaMetS TAAcONa 97 % > 99 % > 99 %
Initial Concentration: 188 ppm in THF 110 ppm in THF 6 ppm in THF
Conditions: 4 eq. of SiliaMetS (according to palladium), 4 h, 22°C.