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Synthesis of a Multivalent Glycoligand against Avian and Human Influenza Viruses

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A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition.

The prepared glycopolymer with pendant 3’-sialyllactose moieties strongly interacted with both avian & human influenza viruses.

SiliaMetS Imidazole was successful in removing contaminating Cu, with only 5 equiv., O.N. at r.t. (see scheme below).

Tanaka, T. et al. J. Appl. Glycosci., 2017, 64, 43 - 48

 

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  1. SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts. It can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

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