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SiliaBond Amine-supported Cu nanoparticles: An efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddition (CuAAC)

SiliaBond Amine-supported Cu nanoparticles: An efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddition (CuAAC)

Huisgen azide-alkyne cycloadditions are typically catalyzed by soluble copper salts. By immobilizing Cu on silica, a new catalyst was prepared which showed low leaching and good recyclability while retaining a high reactivity.

SiliaBond Amine can be used to immobilize Cu nanoparticles prepared by metal vapor synthesis. The resulting catalyst has been shown to be very active for both batch and continuous flow chemistry. The high productivity of the catalyst (up to 1689 mol/mol), its reusability and low metal leaching profile make it an attractive option for click chemistry applications. More over, its reaction scope was shown to be wide, opening the door to several 1,4-disubstituted-1,2,3-triazole scaffolds.

Keywords:
Copper, Click chemistry, Huisgen, SiliaBond Amine, Triazoles

> SiliaBond Amine

 

Publication Aminopropyl-silica-supported Cu nanoparticles: An efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddition (CuAAC)
Authors Ravindra P. Jumdea, Claudio Evangelistia, Alessandro Mandolia,b, Nicola Scottia, Rinaldo Psaroa
Organization a CNR, Institute of Molecular Science and Technologies (ISTM), Via G. Fantoli 16/15, 20138 Milan, Italy
b Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 3, 56124 Pisa, Italy
Source Journal of Catalysis, Volume 324, April 2015, Pages 25–31
Date 2015
Reaction scheme Isolation of 13-Methyl-3,4-seco-ent-podocarpanes, rare C18-diterpenoids from the roots of Flueggea virosa by reversed-phase chromatography on SiliaBond C18
Full publication http://www.sciencedirect.com/science/article/pii/S002195171500024X

 

SiliaBond Functionalized Silica Gels

SiliaBond Functionalized Silica Gels

SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis. The backbone of all SiliaBond products is SiliCycle SiliaFlash F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity.

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SiliaBond Functionalized Silica Gels: