SiliaCat ® Heterogeneous Catalysts
- High stability and accurate loading
- Rigid & porous structure
- Compatibility with a wide range of solvents
- Ease of use: no swelling or static charge
- Minimal leaching
- Fast kinetics
Definitions and Calculation Applications using SiliaCat Scientific Publications using SiliaCat
> Looking for the right SiliaCat Heterogeneous Catalyst to use? Our R&D team can find the optimal conditions for you!
The SiliaCat Matrix
Inspired by the ORganically MOdified SILica (ORMOSIL) technology, the SiliaCat family is composed of new and innovative catalysts.
Resulting from the co-condensation of two organosilane monomers by the sol-gel process, the hybrid organic-inorganic materials present the highest stability and reactivity available with heterogeneous catalysts.
Furthermore, the highly cross-linked framework presents a better resistance compared to post-functionalization process.
What are SiliaCat Heterogeneous Catalysts?
Usually, heterogeneous catalysts supported on a silica matrix are immobilized by post-modification of the inorganic support. These supports, however, present a high degree of leaching due to the poor stability of the immobilized phase. For example, with SiliaCat the ligand is directly crosslinked in an organic-inorganic framework. This results in a high degree of stability of the catalysts.
Compared to homogeneous catalysts, SiliaCat exhibits a good reactivity and selectivity with one of the major advantages being that the catalyst is eliminated from the reaction mixture by a simple filtration. Forget your purification problems with our SiliaCat catalysts family!
Features and Benefits of SiliaCat Catalysts
- Reagent concentrated at the surface of the material
Reproducible synthesis with high conversion and yield - Robustness
High thermal and mechanical stability - Rigid and porous structure
No swelling, solvent independent and air stable (no inert conditions required) - Minimal leaching of organoceramic matrix
Easier purification - High and accurate catalyst loading
Less catalyst required over competitive products - High turnover number (TON)
Low catalytic amount required (< 1 mol %) - Reusability
Multi-uses possible - Ease of handling and purification
Free flowing, no static charge Easily removed by simple filtration - Ease of scalability
Scalable from mg up to multi-ton scale - Available in bulk quantities
Can be delivered in large quantities and always in stock
Compatibility with Flow Chemistry and Microwave
With Flow Chemistry
SiliaCat can be used in flow chemistry and it is a very stable catalyst. Simply place the heterogeneous catalyst inside the solid-phase reactor provided with your flow system and letting the catalytic reaction run. Multiple reactors can be placed in serie and can be heated to obtain optimum conversions and yields.
With Microwave-Assisted Chemistry
Reactions catalyzed with SiliaCat can also be done under microwave irradiation to provide excellent yields in just minutes. Add all products listed for each procedure to a microwave tube equipped with a magnetic stirrer and set microwave conditions to:
- Power: 150 W
- Pressure: 150 psi
- Temperature: 75 - 150°C
- Reaction Time: 5 - 15 min
Some optimization can be required but these settings are a good starting point.
Use the same work-up conditions provided for each procedure.
A safer alternative to pyrophoric Pd/C or Raney Nickel
Unlike its homogeneous counterparts – which are air unstable and pyrophoric – SiliaCat ORMOSIL-entrapped palladium catalyst Pd0 shows a much better stability.
When testing its flammability limits, it was only under special conditions which took us several hours to identify via trial and error that the Pd nanobeads finally did turn incandescent, and this was over the limit of 350°C of the laser thermometer. This was due to the exothermic reaction between MeOH vapors and atmospheric O2.
Yet, no flames from the catalyst structure were ever spotted under any applied conditions and it was only the color of the white filter paper in the Büchner funnel that turned brown, but never incandescent.
References
Catal. Sci. Technol., 2011, 1, 736 – 739
Catal. Lett., 2012, 142, 213 – 217
Org. Proc. Res. & Dev., 2015, 19, 755 − 768
Catal. Sci. & Technol., 2016, 6, 4657 – 5220
ChemCatChem., 2012, 4, 432 – 445
Béland, F; Pagliaro, M. et al. Org. Process Res. Dev., 2018, XX, XXXX (DOI: 10.1021/acs.oprd.8b00242)
SiliaCat - Regulatory Information
SiliaCat Heterogeneous Catalysts are being used more and more by GMP pharmaceutical, biotechnology, and fine chemical industries as well as contract research and manufacturing organizations. Many have run their own analysis proving SiliaCat can safely be used without compromising the purity of their compounds due to leaching.
SiliCycle is committed to high quality standards and strives to provide default-free products. In doing so, all products are manufactured in an ISO 9001:2008 compliant facility and submitted to a stringent quality control. Every lot must meet the quality specifications to be released for sale and a sample from every batch is kept for subsequent analysis.
All products are shipped with the following information:
- Certificate of Analysis (CoA)
- Purity (Leachables and extractables)
- Molecular loading
- Surface Coverage
- Volatile Content
- Material Safety Data Sheets (MSDS)
- BSE/TSE Declaration (no animal origin)
- Relevant Technical Information
Need specific regulatory files?
SiliCycle can work with you to fulfill your requirements. We can provide custom regulatory documentations that include specific analytical tests in line with your needs.
