SiliaChrom HPLC Column Selection Guide by Manufacturer

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To find a suitable SiliCycle alternative to another manufacturer's columns, refer to the selection guide below.

SiliCycle's alternative phases are selected based on physical and chemical similarities. These alternatives are not guaranteed to provide the same retention or selectivity, but should be sufficiently similar in character to allow a similar or improved separation to be achieved after some method optimization.

The user should refer to the individual phase information to ensure that the characteristics of the alternative match the requirements of their separation. SiliCycle takes no responsibility for any error or omission relating to this information.
All trademarks and registered trademarks are the property of their respective owners.

Manufacturers

 

Advanced Chromatography Technologies^™ (ACT)

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
ACE™ C18 100	100 Å	300 m2/g	15.5 %	NF	SiliaChrom Plus C18
ACE™ C8	100 Å	300 m2/g	9 %	NF	SiliaChrom Plus C8
ACE™ Phenyl	100 Å	300 m2/g	9.5 %	NF	SiliaChrom Plus Phenyl
Ace™ AQ	100 Å	300 m2/g	14 %	NF	SiliaChrom dt C18
Ace™ C18-300	300 Å	100 m2/g	9 %	Yes	SiliaChrom Plus C18-300
Ace™ C8-300	300 Å	100 m2/g	5 %	Yes	SiliaChrom Plus C8-300
Ace™ C4-300	300 Å	100 m2/g	2.6 %	Yes	SiliaChrom Plus C4-300

Agilent Technologies^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Zorbax™ SB-C18	300 Å	45 m2/g	3 %	No	SiliaChrom Plus C18-300
Zorbax™ SB-C8	300 Å	45 m2/g	2 %	No	SiliaChrom Plus C8-300

GL Sciences^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Inertsil™ C4	150 Å	320 m2/g	8 %	Yes	SiliaChrom Plus C4
Inertsil™ Phenyl	150 Å	320 m2/g	10 %	Yes	SiliaChrom Plus Phenyl
Inertsil™ C8	150 Å	320 m2/g	11 %	Yes	SiliaChrom Plus C8
Inertsil™ ODS2	150 Å	320 m2/g	18.5 %	Yes	SiliaChrom dt C18
Inertsil™ ODS3 or ODS3V	100 Å	450 m2/g	15 %	Yes	SiliaChrom Plus C18

Grace Discovery Sciences^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Alltima™ HP C18 AQ	100 Å	450 m2/g	2 %	Yes	SiliaChrom dt C18
Vydac™ 208TP	300 Å	60-110 m2/g	8 %	Yes	SiliaChrom Plus C8-300
Vydac™ 214TP	300 Å	60-110 m2/g	4 %	Yes	SiliaChrom Plus C4-300
Vydac™ 218TP	300 Å	60-110 m2/g	8 %	Yes	SiliaChrom Plus C18-300

Kromasil^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Kromasil™ C18	100 Å	340 m2/g	19 %	Yes	SiliaChrom dt C18
Kromasil™ C8	100 Å	340 m2/g	12 %	Yes	SiliaChrom Plus C8
Kromasil™ C4	100 Å	340 m2/g	8 %	Yes	SiliaChrom Plus C4
Kromasil™ Silica	100 Å	340 m2/g	-	No	SiliaChrom Plus Silica

Macherey-Nagel^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Nucleodur™ C18ec	110 Å	340 m2/g	18 %	Yes	SiliaChrom dt C18
Nucleodur™ C18	110 Å	340 m2/g	18 %	Yes	SiliaChrom dt C18
Nucleodur™ CN	110 Å	340 m2/g	7 %	Yes	SiliaChrom Plus CN
Nucleosil™ C18	100 Å	350 m2/g	15 %	Yes	SiliaChrom Plus C18
Nucleosil™ C8	100 Å	350 m2/g	9 %	No	SiliaChrom Plus C8
Nucleosil™ C6H5 (Phenyl)	100 Å	350 m2/g	8 %	No	SiliaChrom Plus Phenyl
Nucleosil™ CN	100 Å	350 m2/g	5 %	No	SiliaChrom Plus CN
Nucleosil™ NH2	100 Å	350 m2/g	3.5 %	No	SiliaChrom Plus NH2
Nucleosil™ OH (Diol)	100 Å	350 m2/g	NF	NF	SiliaChrom Plus Diol
Nucleosil™ SA	100 Å	350 m2/g	7 %	No	SiliaChrom Plus SCX
Nucleosil™ Silica	100 Å	350 m2/g	-	No	SiliaChrom Plus Silica
Nucleosil™ 300 C18	300 Å	100 m2/g	6.5 %	Yes	SiliaChrom Plus C18-300
Nucleosil™ 300 C8	300 Å	100 m2/g	3 %	Yes	SiliaChrom Plus C8-300
Nucleosil™ 300 C4	300 Å	100 m2/g	2 %	Yes	SiliaChrom Plus C4-300

Phenomenex^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
AQUA™ C18	125 Å	320 m2/g	15 &	Yes, proprietary	SiliaChrom dt C18
Luna™ C18 (2)	100 Å	400 m2/g	17.5 %	Yes	SiliaChrom Plus C18
Luna™ C8	100 Å	440 m2/g	14.75 %	Yes	SiliaChrom Plus C8
Luna™ C8 (2)	100 Å	400 m2/g	13.5 %	Yes	SiliaChrom Plus C8
Luna™ CN	100 Å	400 m2/g	7 &	Yes	SiliaChrom Plus CN
Luna™ NH2	100 Å	400 m2/g	9.5 %	No	SiliaChrom Plus NH2
Luna™ PFP (2)	100 Å	400 m2/g	11.5 %	Yes	SiliaChrom Plus PFP
Luna™ SCX	100 Å	400 m2/g	N/A	No	SiliaChrom Plus SCX
Luna™ Silica (2)	100 Å	400 m2/g	-	No	SiliaChrom Plus Silica
Synergi™ Hydro-RP	80 Å	475 m2/g	19 %	Yes, proprietary	SiliaChrom dt C18
Prodigy™ C8	150 Å	310 m2/g	13 %	Yes	SiliaChrom Plus C8
Prodigy™ ODS2	150 Å	310 m2/g	18 %	Yes	SiliaChrom Plus C18
Prodigy™ ODS-3	100 Å	450 m2/g	16 %	Yes	SiliaChrom Plus C18
Prodigy™ ODS-3V	100 Å	450 m2/g	16 %	NF	SiliaChrom Plus C18
Gemini™ C18	110 Å	375 m2/g	14 %	Yes	SiliaChrom Plus C18
Jupiter™ C18	300 Å	170 m2/g	13 %	Yes	SiliaChrom Plus C18-300
Jupiter™ C4	300 Å	170 m2/g	5 %	Yes	SiliaChrom Plus C4-300

Supelco^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Ascentis™ C18	100 Å	450 m2/g	25 %	Yes	SiliaChrom Plus C18
Ascentis™ C8	100 Å	450 m2/g	15 %	Yes	SiliaChrom Plus C8

Thermo Scientific^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Syncronis™ C18	100 Å	320 m2/g	16 %	Yes	SiliaChrom Plus C18
Syncronis™ C8	100 Å	320 m2/g	10 %	Yes	SiliaChrom Plus C8
Syncronis™ AQ	100 Å	320 m2/g	19 %	Yes, polar	SiliaChrom dt C18
Syncronis™ Phenyl	100 Å	320 m2/g	11 %	Yes	SiliaChrom Plus Phenyl
Syncronis™ Amino	100 Å	320 m2/g	4 %	Yes	SiliaChrom Plus Amino
Syncronis™ Silica	100 Å	320 m2/g	-	No	SiliaChrom Plus Silica
Acclaim™ 120 C18	120 Å	300 m2/g	18 %	Yes	SiliaChrom Plus C18
Acclaim™ 300 C18	300 Å	100 m2/g	8 %	Yes	SiliaChrom Plus C18-300

Waters Corporation^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
Atlantis™ T3	100 Å	300 m2/g	14 %	Yes	SiliaChrom dt C18
SunFire™ C18	100 Å	340 m2/g	16 %	Yes	SiliaChrom Plus C18
SunFire™ C8	100 Å	340 m2/g	12 %	Yes	SiliaChrom Plus C8
SunFire™ Silica	100 Å	340 m2/g	NF	NF	SiliaChrom Plus Silica
Symmetry™ C18	100 Å	335 m2/g	19 %	Yes	SiliaChrom dt C18
Symmetry™ C8	100 Å	335 m2/g	12 %	Yes	SiliaChrom Plus C8

YMC^™

Phase	Pore size	Surface Area	Carbon Load	Endcapping	Recommended Alternative
YMC-Pack™ C4	120 Å	300 m2/g	7 %	Yes	SiliaChrom Plus C4
YMC-Pack™ C8	120 Å	300 m2/g	10 %	Yes	SiliaChrom Plus C8
YMC-Pack™ ODS-AQ	120 Å	300 m2/g	14 %	Yes, proprietary	SiliaChrom dt C18
YMC-Pack™ ODS-A	120 Å	300 m2/g	17 %	Yes	SiliaChrom Plus C18
YMC-Pack™ ODS-A	300 Å	150 m2/g	7 %	Yes	SiliaChrom Plus C18-300
YMC-Pack™ CN	120 Å	300 m2/g	7 %	Yes	SiliaChrom Plus CN
YMC-Pack™ Diol-NP	120 Å	300 m2/g	NF	NF	SiliaChrom Plus Diol
YMC-Pack™ NH2	120 Å	300 m2/g	NF	NF	SiliaChrom Plus NH2
YMC-Pack™ Phenyl	120 Å	300 m2/g	9 %	Yes	SiliaChrom Plus Phenyl
YMC-Pack™ Pro C18	120 Å	350 m2/g	16 %	Yes	SiliaChrom Plus C18
YMC-Pack™ Si	120 Å	300 m2/g	-	No	SiliaChrom Plus Silica

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