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SiliaChrom HPLC Column Selection Guide by Manufacturer

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To find a suitable SiliCycle alternative to another manufacturer's columns, refer to the selection guide below.

SiliCycle's alternative phases are selected based on physical and chemical similarities. These alternatives are not guaranteed to provide the same retention or selectivity, but should be sufficiently similar in character to allow a similar or improved separation to be achieved after some method optimization.

The user should refer to the individual phase information to ensure that the characteristics of the alternative match the requirements of their separation. SiliCycle takes no responsibility for any error or omission relating to this information.
All trademarks and registered trademarks are the property of their respective owners.

Manufacturers

 

Advanced Chromatography Technologies (ACT)

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
ACE C18 100 100 Å300 m2/g15.5 %NFSiliaChrom Plus C18
ACE C8 100 Å300 m2/g9 %NFSiliaChrom Plus C8
ACE Phenyl 100 Å300 m2/g9.5 %NFSiliaChrom Plus Phenyl
Ace AQ100 Å300 m2/g14 %NFSiliaChrom dt C18
Ace C18-300300 Å100 m2/g9 %YesSiliaChrom Plus C18-300
Ace C8-300300 Å100 m2/g5 %YesSiliaChrom Plus C8-300
Ace C4-300300 Å100 m2/g2.6 %YesSiliaChrom Plus C4-300

Agilent Technologies

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Zorbax SB-C18300 Å45 m2/g3 %NoSiliaChrom Plus C18-300
Zorbax SB-C8300 Å45 m2/g2 %NoSiliaChrom Plus C8-300

GL Sciences

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Inertsil C4150 Å320 m2/g8 %YesSiliaChrom Plus C4
Inertsil Phenyl150 Å320 m2/g10 %YesSiliaChrom Plus Phenyl
Inertsil C8150 Å320 m2/g11 %YesSiliaChrom Plus C8
Inertsil ODS2150 Å320 m2/g18.5 %YesSiliaChrom dt C18
Inertsil ODS3 or ODS3V100 Å450 m2/g15 %YesSiliaChrom Plus C18

Grace Discovery Sciences

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Alltima HP C18 AQ100 Å450 m2/g2 %YesSiliaChrom dt C18
Vydac 208TP300 Å60-110 m2/g8 %YesSiliaChrom Plus C8-300
Vydac 214TP300 Å60-110 m2/g4 %YesSiliaChrom Plus C4-300
Vydac 218TP300 Å60-110 m2/g8 %YesSiliaChrom Plus C18-300

Kromasil

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Kromasil C18100 Å340 m2/g19 %YesSiliaChrom dt C18
Kromasil C8100 Å340 m2/g12 %YesSiliaChrom Plus C8
Kromasil C4100 Å340 m2/g8 %YesSiliaChrom Plus C4
Kromasil Silica100 Å340 m2/g-NoSiliaChrom Plus Silica

Macherey-Nagel

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Nucleodur C18ec110 Å340 m2/g18 %YesSiliaChrom dt C18
Nucleodur C18110 Å340 m2/g18 %YesSiliaChrom dt C18
Nucleodur CN110 Å340 m2/g7 %YesSiliaChrom Plus CN
Nucleosil C18100 Å350 m2/g15 %YesSiliaChrom Plus C18
Nucleosil C8 100 Å350 m2/g9 %NoSiliaChrom Plus C8
Nucleosil C6H5 (Phenyl)100 Å350 m2/g8 %NoSiliaChrom Plus Phenyl
Nucleosil CN100 Å350 m2/g5 %NoSiliaChrom Plus CN
Nucleosil NH2100 Å350 m2/g3.5 %NoSiliaChrom Plus NH2
Nucleosil OH (Diol)100 Å350 m2/gNFNFSiliaChrom Plus Diol
Nucleosil SA100 Å350 m2/g7 %NoSiliaChrom Plus SCX
Nucleosil Silica100 Å350 m2/g-NoSiliaChrom Plus Silica
Nucleosil 300 C18300 Å100 m2/g6.5 %YesSiliaChrom Plus C18-300
Nucleosil 300 C8300 Å100 m2/g3 %YesSiliaChrom Plus C8-300
Nucleosil 300 C4300 Å100 m2/g2 %YesSiliaChrom Plus C4-300

Phenomenex

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
AQUA C18125 Å320 m2/g15 &Yes, proprietarySiliaChrom dt C18
Luna C18 (2)100 Å400 m2/g17.5 %YesSiliaChrom Plus C18
Luna C8100 Å440 m2/g14.75 %YesSiliaChrom Plus C8
Luna C8 (2)100 Å400 m2/g13.5 %YesSiliaChrom Plus C8
Luna CN100 Å400 m2/g7 &YesSiliaChrom Plus CN
Luna NH2100 Å400 m2/g9.5 %NoSiliaChrom Plus NH2
Luna PFP (2)100 Å400 m2/g11.5 %YesSiliaChrom Plus PFP
Luna SCX100 Å400 m2/gN/ANoSiliaChrom Plus SCX
Luna Silica (2)100 Å400 m2/g-NoSiliaChrom Plus Silica
Synergi Hydro-RP80 Å475 m2/g19 %Yes, proprietarySiliaChrom dt C18
Prodigy C8150 Å310 m2/g13 %YesSiliaChrom Plus C8
Prodigy ODS2150 Å310 m2/g18 %YesSiliaChrom Plus C18
Prodigy ODS-3100 Å450 m2/g16 %YesSiliaChrom Plus C18
Prodigy ODS-3V100 Å450 m2/g16 %NFSiliaChrom Plus C18
Gemini C18110 Å375 m2/g14 %YesSiliaChrom Plus C18
Jupiter C18300 Å170 m2/g13 %YesSiliaChrom Plus C18-300
Jupiter C4300 Å170 m2/g5 %YesSiliaChrom Plus C4-300

Supelco

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Ascentis C18100 Å450 m2/g25 %YesSiliaChrom Plus C18
Ascentis C8100 Å450 m2/g15 %YesSiliaChrom Plus C8

Thermo Scientific

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Syncronis C18100 Å320 m2/g16 %YesSiliaChrom Plus C18
Syncronis C8100 Å320 m2/g10 %YesSiliaChrom Plus C8
Syncronis AQ100 Å320 m2/g19 %Yes, polarSiliaChrom dt C18
Syncronis Phenyl100 Å320 m2/g11 %YesSiliaChrom Plus Phenyl
Syncronis Amino100 Å320 m2/g4 %YesSiliaChrom Plus Amino
Syncronis Silica100 Å320 m2/g-NoSiliaChrom Plus Silica
Acclaim 120 C18120 Å300 m2/g18 %YesSiliaChrom Plus C18
Acclaim 300 C18300 Å100 m2/g8 %YesSiliaChrom Plus C18-300

Waters Corporation

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
Atlantis T3100 Å300 m2/g14 %YesSiliaChrom dt C18
SunFire C18100 Å340 m2/g16 %YesSiliaChrom Plus C18
SunFire C8100 Å340 m2/g12 %YesSiliaChrom Plus C8
SunFire Silica100 Å340 m2/gNFNFSiliaChrom Plus Silica
Symmetry C18100 Å335 m2/g19 %YesSiliaChrom dt C18
Symmetry C8100 Å335 m2/g12 %YesSiliaChrom Plus C8

YMC

PhasePore sizeSurface AreaCarbon LoadEndcappingRecommended Alternative
YMC-Pack C4120 Å300 m2/g7 %YesSiliaChrom Plus C4
YMC-Pack C8120 Å300 m2/g10 %YesSiliaChrom Plus C8
YMC-Pack ODS-AQ120 Å300 m2/g14 %Yes, proprietarySiliaChrom dt C18
YMC-Pack ODS-A120 Å300 m2/g17 %YesSiliaChrom Plus C18
YMC-Pack ODS-A300 Å150 m2/g7 %YesSiliaChrom Plus C18-300
YMC-Pack CN120 Å300 m2/g7 %YesSiliaChrom Plus CN
YMC-Pack Diol-NP120 Å300 m2/gNFNFSiliaChrom Plus Diol
YMC-Pack NH2120 Å300 m2/gNFNFSiliaChrom Plus NH2
YMC-Pack Phenyl120 Å300 m2/g9 %YesSiliaChrom Plus Phenyl
YMC-Pack Pro C18120 Å350 m2/g16 %YesSiliaChrom Plus C18
YMC-Pack Si120 Å300 m2/g-NoSiliaChrom Plus Silica

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