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SiliaSep PREMIUM

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Packed with SiliCycle's 25 μm spherical silica gel, SiliaSep PREMIUM flash cartridges will give you better resolution for difficult purifications, sharper peaks, higher loading capacity and faster separations.

  • Clean pre-packed, disposable polypropylene cartridges
  • Leak-free guaranteed
  • Made with high quality SiliaSphere® PC (25 µm, 90 Å)
  • Tight particle size distribution
  • Low fines
  • Neutral pH
  • Controlled water content
  • Very diversified formats (4, 12, 25, 40, 80, 120, 220, 330, 800 & 1,600 g)
  • Effective packing technology
  • Stringent quality control (Registered ISO 9001:2015)
  • Lot-to-lot reproducibility

SiliaSep PREMIUM Scalability

SiliaSep PREMIUM perfect linearity between all formats, from 4 g cartridges to XL 1,600 g cartridges, will allow you to easily scale-up your methods and transfer your preliminary tests onto bigger cartridges sizes.

To highlight the scalability, you will find below the purification of a solution of Aniline, Anisole and Benzoic Acid in DMSO on SiliaSep PREMIUM C18 25 g and 330 g. You can see that the chromatograms are almost identical!

Chromatographic Conditions

  • Mobile phase: gradient Water / Methanol (90:10 to 0:100)
  • Flow rate: 40 mL/min
  • Injection volume: 0.5 mL
  • Wavelength: 254 nm

SiliaSep PREMIUM Scalability

SiliaSep PREMIUM against the Competition

We compared the results on our SiliaSep PREMIUM with two well known brands in chromatography and purification. This study shows that SiliaSep PREMIUM cartridges perform very well and represent a valuable and reliable alternative.

Chromatographic Conditions

  • Mobile phase: gradient Water / Methanol (90:10 to 0:100)
  • Flow rate: 40 mL/min
  • Injection volume: 0.5 mL
  • Wavelength: 254 nm

SiliaSep PREMIUM Scalability

 

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  1. SiliaSep PREMIUM Flash Cartridges, C18 Monomeric, 25 µm (FLH-03295D-A)

    SiliaSep PREMIUM Flash Cartridges, C18, spherical 25 µm (FLH-03295D-A)

    Indicated for the purification of low to high polarity compounds. Provides reproducible purification without the complexity and cost of preparative HPLC.
  2. SiliaSep Flash Cartridges, Silica, 25 µm (FLH-10095D-A)

    SiliaSep PREMIUM Flash Cartridges, Silica, spherical 25 µm (FLH-10095D-A)

    Most popular sorbent for day-to-day use for the purification of non-ionic polar organic compounds.
  3. SiliaSep Flash Cartridges, Diol, 25 µm (FLH-35095D-A)

    SiliaSep PREMIUM Flash Cartridges, Diol, spherical 25 µm (FLH-35095D-A)

    Good alternative for difficult separation of low to medium polarity samples. Useful for mono and polysaccharides separation. Can be used in HILIC mode.
  4. SiliaSep Flash Cartridges, C8 Monomeric, 25 µm (FLH-30895D-A)

    SiliaSep PREMIUM Flash Cartridges, C8, spherical 25 µm (FLH-30895D-A)

    Presents less retention compared to C18. Typically used for highly hydrophobic pesticides, small peptides and large molecule drugs.
  5. SiliaSep Flash Cartridges, Amine (WAX), 25 µm (FLH-52095D-A)

    SiliaSep PREMIUM Flash Cartridges, Amine (WAX), spherical 25 µm (FLH-52095D-A)

    The amine phase can be used either in normal phase for the purification of compounds with basic properties & for monosaccharides separation; or as a weak anion exchanger (pKa of 9.8). At pH 7.8 or below, the functional groups are positively charged. It facilitates the rapid release of very strong anions such as sulfonic acids that may be too strongly retained on SAX.

  6. SiliaSep PREMIUM Flash Cartridges, C4, spherical 25 µm (FLH-32095D-A)

    SiliaSep PREMIUM Flash Cartridges, C4, spherical, 25 µm, 90 Å (FLH-32095D-A)

    Presents less retention compared to C18 and C8. Widely used for molecules with large hydrophobic regions.
  7. SiliaSep PREMIUM Flash Cartridges, Phenyl, spherical, 25 µm, 90 Å (FLH-34095D-A)

    SiliaSep PREMIUM Flash Cartridges, Phenyl, spherical, 25 µm, 90 Å (FLH-34095D-A)

    Moderate non-polar sorbent with different selectivity for aromatic compounds compared to other non-polar sorbents.
  8. SiliaSep PREMIUM Flash Cartridges, Pentafluorophenyl (PFP), 25 µm, 90 Å (FLH-67595D-A)

    SiliaSep PREMIUM Flash Cartridges, Pentafluorophenyl (PFP), 25 µm, 90 Å (FLH-67595D-A)

    For a new selectivity approach with aromatic ring interactions, or for the purification of conjugated compounds (isomers).
  9. SiliaSep PREMIUM Flash Cartridges, Cyano (CN), 25 µm, 90 Å (FLH-38095D-A)

    SiliaSep PREMIUM Flash Cartridges, Cyano (CN), 25 µm, 90 Å (FLH-38095D-A)

    Versatile sorbent that can be used either as normal or reversed-phase. Indicated for products with intermediate to extreme polarity. The slightly hydrophobic nature of the cyano group offers alternative selectivity.
  10. SiliaSep PREMIUM Flash Cartridges SAX nec (TMA Chloride), 25 µm, 90 Å (FLH-66595D-A)

    SiliaSep PREMIUM Flash Cartridges SAX nec (TMA Chloride), 25 µm, 90 Å (FLH-66595D-A)

    The quaternary amine is permanently charged (pH independent). It is commonly used for the extraction of weak anions (such as carboxylic acids) that may not bind strongly enough to weaker anion exchangers. Analysis of acidic drugs and analgesics, biomolecules (peptides and proteins) and water-soluble vitamins (vitamins B and C).
  11. SiliaSep PREMIUM Flash Cartridges SAX-2 nec (TMA Acetate), 25 µm, 90 Å (FLH-66495D-A)

    SiliaSep PREMIUM Flash Cartridges SAX-2 nec (TMA Acetate), 25 µm, 90 Å (FLH-66495D-A)

    The acetate counter-ion is easily exchangeable (more than the chloride ion) for compounds with pKa < 5, such as carboxylic acids. This phase can be used in organic chemistry applications to selectively purify acidic compounds or remove acidic impurities from reaction mixtures.
  12. SiliaSep PREMIUM Flash Cartridges, SCX (Tosic Acid), 25 µm, 90 Å (FLH-60595D-A)

    SiliaSep PREMIUM Flash Cartridges, SCX (Tosic Acid), 25 µm, 90 Å (FLH-60595D-A)

    Due to the very low pKa (< 1) these functions are strong cation exchangers since they maintain a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations (for example basic drugs and analgesics), analysis of basic biomolecules (peptides and proteins) and water-soluble vitamins (basic vitamins B and C).
  13. SiliaSep PREMIUM Flash Cartridges, SCX-2 (Propylsulfonic Acid), 25 µm, 90 Å (FLH-51295D-A)

    SiliaSep PREMIUM Flash Cartridges, SCX-2 (Propylsulfonic Acid), 25 µm, 90 Å (FLH-51295D-A)

    Due to the very low pKa (< 1) these functions are strong cation exchangers since they maintain a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations (for example basic drugs and analgesics), analysis of basic biomolecules (peptides and proteins) and water-soluble vitamins (basic vitamins B and C).

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