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SiliaSep Flash Cartridges - Ion Exchange Phases

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In ion exchange mode, the silica support is modified by a function carrying a charge with its counter-ion. This counter-ion is exchangeable with other ions in solution.

  • If the immobilized phase is carrying an anion, the exchangeable species is a cation.
  • Inversely, if the immobilized phase carries a cation, the ion exchangeable species will be an anion.

Ion exchange phases are widely used in separation and purification.

SiliaSep Description
SiliaSep SAX nec
(TMA Chloride)
FLH-R66530B
The quaternary amine is permanently charged (pH independent). It is commonly used for the extraction of weak anions (such as carboxylic acids) that may not bind strongly enough to weaker anion exchangers. Analysis of acidic drugs and analgesics, biomolecules (peptides and proteins) and water-soluble vitamins (vitamins B and C).
SiliaSep SAX-2 nec
(TMA Acetate)
FLH-R66430B
The acetate counter-ion is easily exchangeable (more than the chloride ion) for compounds with pKa < 5, such as carboxylic acids. This phase can be used in organic chemistry applications to selectively purify acidic compounds or remove acidic impurities from reaction mixtures.
SiliaSep WAX
(Amine)
FLH-R52030B
A weak anion exchanger with a pKa of 9.8. At pH 7.8 or below, the functional groups are positively charged. It facilitates the rapid release of very strong anions such as sulfonic acids that may be too strongly retained on SAX.
SiliaSep WCX
(Carboxylic Acid)
FLH-R70030B
A weak cation exchanger with a pKa of 4.8. A pH of 2.8 or below is needed to neutralize the phase and easily elute strong cationic analytes that are neutralized only at extreme basic conditions. This phase is commonly used for the extraction of strong cationic species, which would bind too strongly to strong cation exchangers.
SiliaSep WAX-2
(Diethylamine)
FLH-R76530B
With a pKa of 10.5, this phase is preferred over SAX when performing catch and release purification of compounds bearing a permanent negative charge such as salts of sulfonic acids. Using SAX in this case could make the release of the compound of interest difficult (but not necessarily impossible) due to the strong interaction between the two strong ions.
SiliaSep SCX
(Tosic Acid)
FLH-R60530B
Due to the very low pKa (< 1) these functions are strong cation exchangers since they maintain a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations (for example basic drugs and analgesics), analysis of basic biomolecules (peptides and proteins) and water-soluble vitamins (basic vitamins B and C).
SiliaSep SCX-2
(Propylsulfonic Acid)
FLH-R51230B

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  1. SiliaSep Flash Cartridges, WCX, 40 - 63 µm, 60 Å (FLH-R70030B)
  2. SiliaSep Flash Cartridges, TMA Chloride (SAX) nec, 40 - 63 µm, 60 Å (FLH-R66530B)

    SiliaSep Flash Cartridges, TMA Chloride (SAX) nec, 40 - 63 µm, 60 Å (FLH-R66530B)

    Packed with a strong anion exchanger, they can be used to fully retain acidic compounds for clean-up or to isolate them by "catch and release" process.
  3. SiliaSep Flash Cartridges, TMA Acetate (SAX-2) nec, 40 - 63 µm, 60 Å (FLH-R66430B)

    SiliaSep Flash Cartridges, TMA Acetate (SAX-2) nec, 40 - 63 µm, 60 Å (FLH-R66430B)

    Packed with a strong anion exchanger, they can be used to fully retain acidic compounds for clean-up or to isolate them by "catch and release" process. The acetate counter-ion is easily exchangeable (more than the chloride ion).
  4. SiliaSep Flash Cartridges, Amine (WAX), 40 - 63 µm, 60 Å (FLH-R52030B)

    SiliaSep Flash Cartridges, Amine (WAX), 40 - 63 µm, 60 Å (FLH-R52030B)

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase. Also a weak anion exchanger, with a pKa of 9.8. At pH 7.8 or below, the functional groups are positively charged. It facilitates the rapid release of very strong anions such as sulfonic acids that may be too strongly retained on SAX.
  5. SiliaSep Flash Cartridges, Diamine, 40 - 63 µm, 60 Å (FLH-R49030B)

    SiliaSep Flash Cartridges, Diamine, 40 - 63 µm, 60 Å (FLH-R49030B)

    Well known for its electrophile scavenging efficiency and its base reagent quality, Diamine has also proven to be very useful for the scavenging of various metals.
  6. SiliaSep Flash Cartridges, Triamine, 40 - 63 µm, 60 Å (FLH-R48030B)

    SiliaSep Flash Cartridges, Triamine, 40 - 63 µm, 60 Å (FLH-R48030B)

    Well known for its electrophile scavenging efficiency and its base reagent quality, Triamine has also proven to be very useful for the scavenging of various metals. Best scavenger for: Cr, Pd, Pt, W & Zn. Good scavenger for: Ag, Cd, Co, Cu, Fe, Hg, Ni, Os, Pb, Rh, Ru & Sc.
  7. SiliaSep Flash Cartridges, WAX-2, 60 Å, 40 - 63 µm, 60 Å (FLH-R76530B)

    SiliaSep Flash Cartridges, WAX-2, 60 Å, 40 - 63 µm, 60 Å (FLH-R76530B)

    With a pKa of 10.5, this phase is preferred over SAX when performing catch and release purification of compounds bearing a permanent negative charge.
  8. SiliaSep Flash Cartridges,Tosic Acid (SCX), 40 - 63 µm, 60 Å (FLH-R60530B)

    SiliaSep Flash Cartridges,Tosic Acid (SCX), 40 - 63 µm, 60 Å (FLH-R60530B)

    Due to the very low pKa (< 1), Tosic Acid is a strong cation exchanger and maintains a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations.
  9. SiliaSep Flash Cartridges, Propylsulfonic Acid (SCX-2), 40 - 63 µm, 60 Å (FLH-R51230B)

    SiliaSep Flash Cartridges, Propylsulfonic Acid (SCX-2), 40 - 63 µm, 60 Å (FLH-R51230B)

    Due to the very low pKa (< 1), Propylsulfonic Acid is a strong cation exchanger and maintains a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations.

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