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Ion Exchange Phases

In ion exchange mode, the silica support is modified by a function carrying a charge with its counter-ion. This counter-ion is exchangeable with other ions in solution. If the immobilized phase is carrying an anion, the exchangeable species is a cation. Inversely, if the immobilized phase carries a cation, the ion exchangeable species will be an anion. Ion exchange phases are widely used in separation and purification.

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  1. SiliaSep Flash Cartridges, TMA Chloride (SAX) nec, 40 - 63 µm, 60 Å (FLH-R66530B)

    SiliaSep Flash Cartridges, TMA Chloride (SAX) nec, 40 - 63 µm, 60 Å (FLH-R66530B)

    The quaternary amine is permanently charged (pH independent). It is commonly used for the extraction of weak anions (such as carboxylic acids) that may not bind strongly enough to weaker anion exchangers. Analysis of acidic drugs and analgesics, biomolecules (peptides and proteins) and water-soluble vitamins (vitamins B and C).
  2. SiliaSep Flash Cartridges, TMA Acetate (SAX-2) nec, 40 - 63 µm, 60 Å (FLH-R66430B)

    SiliaSep Flash Cartridges, TMA Acetate (SAX-2) nec, 40 - 63 µm, 60 Å (FLH-R66430B)

    The acetate counter-ion is easily exchangeable (more than the chloride ion) for compounds with pKa < 5, such as carboxylic acids. This phase can be used in organic chemistry applications to selectively purify acidic compounds or remove acidic impurities from reaction mixtures.
  3. SiliaSep Flash Cartridges, Amine (WAX), 40 - 63 µm, 60 Å (FLH-R52030B)

    SiliaSep Flash Cartridges, Amine (WAX), 40 - 63 µm, 60 Å (FLH-R52030B)

    A weak anion exchanger with a pKa of 9.8. At pH 7.8 or below, the functional groups are positively charged. It facilitates the rapid release of very strong anions such as sulfonic acids that may be too strongly retained on SAX.
  4. SiliaSep Flash Cartridges, Diamine, 40 - 63 µm, 60 Å (FLH-R49030B)

    SiliaSep Flash Cartridges, Diamine, 40 - 63 µm, 60 Å (FLH-R49030B)

    SiliaSep flash diamine cartridges offer a superior alternative to the other cartridges available on the market.

  5. SiliaSep Flash Cartridges, Triamine, 40 - 63 µm, 60 Å (FLH-R48030B)

    SiliaSep Flash Cartridges, Triamine, 40 - 63 µm, 60 Å (FLH-R48030B)

    SiliaSep flash triamine cartridges offer a superior alternative to the other cartridges available on the market.

  6. SiliaSep Flash Cartridges, WAX-2, 60 Å, 40 - 63 µm, 60 Å (FLH-R76530B)

    SiliaSep Flash Cartridges, WAX-2, 60 Å, 40 - 63 µm, 60 Å (FLH-R76530B)

    With a pKa of 10.5, this phase is prefered over SAX when performing catch and release purification of compounds bearing a permanent negative charge such as salts of sulfonic acids. Using SAX in this case could make the release of the compound of interest difficult (but not necessarily impossible) due to the strong interaction between the two strong ions.
  7. SiliaSep Flash Cartridges,Tosic Acid (SCX), 40 - 63 µm, 60 Å (FLH-R60530B)

    SiliaSep Flash Cartridges,Tosic Acid (SCX), 40 - 63 µm, 60 Å (FLH-R60530B)

    Due to the very low pKa (< 1) these functions are strong cation exchangers since they maintain a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations (for example basic drugs and analgesics), analysis of basic biomolecules (peptides and proteins) and water-soluble vitamins (basic vitamins B and C).
  8. SiliaSep Flash Cartridges, Propylsulfonic Acid (SCX-2), 40 - 63 µm, 60 Å (FLH-R51230B)

    SiliaSep Flash Cartridges, Propylsulfonic Acid (SCX-2), 40 - 63 µm, 60 Å (FLH-R51230B)

    Due to the very low pKa (< 1) these functions are strong cation exchangers since they maintain a negative charge throughout the pH scale. The most common use is likely for catch and release purification of weak cations (for example basic drugs and analgesics), analysis of basic biomolecules (peptides and proteins) and water-soluble vitamins (basic vitamins B and C).
  9. SiliaSep Flash Cartridges, Bicarbonate, 40 - 63 µm, 60 Å (FLH-R65830B)

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