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SiliCycle MiniBlock® Family

Multifunctional synthesis platforms

Originally designed by chemists and engineers at Bristol-Myers Squibb, the SiliCycle MiniBlock® Family has been further developed to address a wide range of chemistry methodologies and meet your project deadlines!

  • Solution & Solid-Phase Synthesis
  • Peptide Synthesis
  • Library Synthesis / Combinatorial Chemistry
  • Multi-Step Synthesis
  • Screenings
  • Scavenging Studies
  • Reflux and Inerting
  • Parallel Purification & Filtration

The SiliCycle MiniBlock Family is widely used by chemists in the pharmaceutical, academic, biopharma, chemical, petrochemical and polymer industries. The flexibility of the design allows chemists to rapidly configure these compact parallel reactors to fit the needs of their chemistry, whether it requires inert conditions, refluxing or cooling, allowing complete freedom to choose a synthetic route.

Furthermore, these easy-to-use reaction blocks are specially designed for parallel synthesis and screening reactions. They enable you to achieve multiple reactions simultaneously, using similar amounts of time, energy and starting materials, as it would usually require for a single experiment.

 

Available documentation about the SiliCycle MiniBlock Family

 

Features and Benefits

Function / Specification SiliCycle MiniBlock SiliCycle MiniBlock XT
Solution-Phase Synthesis ✔ ✔
Solid-Phase Synthesis ✔ N/A
SPE ✔ N/A
Scavenger Resins ✔ ✔
Number of Reactors 6, 12, 24, 48, 96 6, 12, 24, 48
Reactors Capacity 40 mL, 20 mL, 10 mL, 4 mL 110 mL, 55 mL, 18 mL, 11.5 mL
Heating 80°C (Polypropylene)
120°C (Glass)		 160°C
Cooling -20°C (Via Recirculator - Not Included) -78°C (Ice Bath)
-20°C (Via Recirculator - Not Included)
Inerting Capability ✔ ✔
Reflux Capability N/A ✔
Mixing Orbital Shaking Stirrer Plate /
Orbital Shaking

 

  • SiliCycle MiniBlock: 6-Positions (40mL), 12-Positions (20mL), 24-Positions (10mL) and 48-Positions (4mL).

    SiliCycle MiniBlock is a flexible, easy-to-use tool that maximizes the productivity of synthetic chemists while reducing development time. It is the only compact parallel synthesizer that allows synthesis via solid or solution-phase as well as purification to be carried out on the same platform. [read more]

  • SiliCycle MiniBlock XT: 6-Positions (110mL), 12-Positions (55mL), 24-Positions (18mL) and 48-Positions (11.5mL).

    The SiliCycle MiniBlock XT is an easy-to-operate system designed for parallel synthesis and screening reactions. Applications include synthesis of small organic molecules, optimization of critical process parameters, and screening for optimal reaction conditions. It is ideal for applications supported by statistical Design of Experiments (DoE). [read more]

 

For more information, please contact us at: miniblock@silicycle.com

 

Since the SiliCycle MiniBlock Family is fully compatible with the entire spectrum of SiliCycle scavengers (metal, organic and GPI scavengers), functionalized silica gels (such as chromatographic phases and reagents), heterogeneous catalysts and all our SPE sorbents (silica-based and polymeric): no need to look any further to find all that you will need for your projects!

 

View the complete MiniBlock® Family Video Library

 

SiliCycle MiniBlock Family in literature

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  1. Multi-Layer Sealing Gasket for Inert/Purge Manifold, 24-Positions (PN 13201042)

    Multi-Layer Sealing Gasket for Inert/Purge Manifold, 24-Positions (PN 13201042)

    Multi-Layer Sealing Gasket for Inert/Purge Manifold, 24-Positions, Advanced Sealing, 5/pk
  2. Sealing Gasket, Ultra Pure Natural Rubber, for Purge/Evap Manifold, 24-Positions (PN 13200994)

    Sealing Gasket, Ultra Pure Natural Rubber, for Purge/Evap Manifold, 24-Positions (PN 13200994)

    Sealing Gasket, Ultra Pure Natural Rubber, for Purge/Evap Manifold, 24-Positions, 5/pk
  3. Inner/Piercing Septa for Purge/Evap Manifold: 24-Positions (PN 13742170)

    Inner/Piercing Septa for Purge/Evap Manifold: 24-Positions (PN 13742170)

    Inner/Piercing Septa for Purge/Evap Manifold: 24-Positions, 5/pk
  4. Magnetic Stir Cross, 3/8 in, 24-positions (PN 13511159)

    Magnetic Stir Cross, 3/8 in, 24-positions (PN 13511159)

    Magnetic Stir Cross, 3/8 in, 24-positions, 30/box
  5. SiliCycle MiniBlock Micro Synthesis Set (24 or 48-Positions)

    SiliCycle MiniBlock Micro Synthesis Set (24 or 48-Positions)

    Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlock can be chosen red or blue.
  6. SiliCycle MiniBlock Micro Synthesis Set 12-Positions

    SiliCycle MiniBlock Micro Synthesis Set 12-Positions

    Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlock can be chosen red or blue.
  7. SiliCycle MiniBlock Compact Synthesis Set (24 or 48-Positions)

    SiliCycle MiniBlock Compact Synthesis Set (24 or 48-Positions)

    Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlocks can be chosen as one of each color (red and blue) or both blocks the same color. Red/Blue combination is required for collection into a 96-Positions format.
  8. SiliCycle MiniBlock Compact Synthesis Set 12-Positions

    SiliCycle MiniBlock Compact Synthesis Set 12-Positions

    Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlocks can be chosen as one of each color (red and blue) or both blocks the same color.
  9. SiliCycle MiniBlock XT Basic Kit

    SiliCycle MiniBlock XT Basic Kit

    Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. For use with magnetic stirrer-heater (not included). Temperature range of -70°C to 160°C. Fully upgradable for reflux and inerting capability. Consumables are included in the price.
  10. SiliCycle MiniBlock XT Complete Kit (refluxing and inerting)

    SiliCycle MiniBlock XT Complete Kit (refluxing and inerting)

    Reactor designed for precision heating and refluxing (temperature range: -70°C to 160°C). For use with magnetic stirrer-heater (not included). Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
  11. SiliCycle MiniBlock XT Set (Complete Reactor with Hotplate Stirrer) - 230V

    SiliCycle MiniBlock XT Set (Complete Reactor with Hotplate Stirrer) - 230V

    Reactor designed for reflux or controlled temperature synthesis (temperature range: -70°C to 160°C). For use with magnetic stirrer-heater. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
  12. SiliCycle MiniBlock XT Set (Complete Reactor with Hotplate Stirrer) - 115V

    SiliCycle MiniBlock XT Set (Complete Reactor with Hotplate Stirrer) - 115V

    Reactor designed for reflux or controlled temperature synthesis (temperature range: -70°C to 160°C). For use with magnetic stirrer-heater. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
  13. SiliCycle MiniBlock XT-Plus Kit

    SiliCycle MiniBlock XT-Plus Kit

    Unique reaction block with built-in liquid circulation, allowing temperature control using a standard heating and cooling recirculator (temperature range of -70°C to 160°C). Heating and cooling of reaction vessels in one step, with a single connection. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Fully upgradable for reflux and inerting capability. Consumables are included in the price.
  14. SiliCycle MiniBlock XT-Plus Complete Kit (refluxing and inerting)

    SiliCycle MiniBlock XT-Plus Complete Kit (refluxing and inerting)

    Unique reaction block with built-in liquid circulation, allowing temperature control using a standard heating and cooling recirculator (temperature range of -70°C to 160°C). Heating and cooling of reaction vessels in one step, with a single connection. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
  15. Shaking and Washing Stations

    Shaking and Washing Stations

    High performance orbital shaker with integrated basins for wash and rinse capability. Customized and configured to provide vigorous vortex mixing for 1 (Micro) or 2 (Compact) SiliCycle MiniBlocks.
  16. SiliCycle MiniBlock Synthesizer

    SiliCycle MiniBlock Synthesizer

    Patented reactor with built-in valve design. Available in 48, 24, 12, and 6-Positions arrays. Reaction vessel volumes are 4 mL, 10 mL, 20 mL and 40 mL respectively (not included).
  17. Reflux Layer / Heat Transfer Block

    Reflux Layer / Heat Transfer Block

    Heating/Cooling Block, allowing uniform cooling to -40°C, and heating to 120°C. Quick to install, efficient condensation. Available in 6, 12, 24 or 48-Positions arrays. Includes quick-disconnect fittings.
  18. Inerting / Purging Manifold (48-Positions)

    Inerting / Purging Manifold (48-Positions)

    Inert gas manifold can be operated in continuous purging or static pressure modes. Internal septum prevents evaporative loss and facilitates reagent addition or reaction sampling. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. For MiniBlock 48-Positions.
  19. Purging / Evaporating Manifold

    Purging / Evaporating Manifold

    For 6,12 and 24-Positions reactors. Provides superior performance for maintaining inert atmosphere while providing a cost effective option for evaporating solvents. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. Includes one box of sealing layer and one box of Inner/Piercing septa.
  20. Transfer Adapter

    Transfer Adapter

    To stack one SiliCycle MiniBlock on top of the other, allowing the transfer of products. Does not fit over heat transfer block!
  21. Insulation Wrap

    Insulation Wrap

    Ensure maximal uniformity between reactors when working under extreme temperatures. Temperature uniformity and reproducibility is within 1°C at 80°C.
  22. Air Push Assist Device

    Air Push Assist Device

    Simple device that helps drain reaction tubes by applying gentle air pressure.
  23. Positive Pressure Manifold

    Positive Pressure Manifold

    Provides positive pressure to all reaction tubes to assist draining. Also used to push solvents from one SiliCycle MiniBlock to a second SiliCycle MiniBlock containing resins/sorbents.
  24. Heat Dispersion Adapter

    Heat Dispersion Adapter

    Focuses heat from stirrer plate unit to XT reactor for uniform temperature distribution to all reaction vessels.
  25. XT Low Temperature Bath

    XT Low Temperature Bath

    Insulated tray for sub-ambient temperature control of one XT reactor. Insulated tray maintains dry ice / acetone temperature for approximately four hours without refilling. Tray can be placed on top of magnetic stirrers for mixing reaction components.
  26. Compact Shaking Station, 115V

    Compact Shaking Station, 115V

    Compact Shaking Station, 115V
  27. Compact Shaking Station, 230V

    Compact Shaking Station, 230V

    Compact Shaking Station, 230V
  28. Counter Weight (Compact Station)

    Counter Weight (Compact Station)

    Counter Weight (Compact Station)
  29. Micro Shaking Station, 115V

    Micro Shaking Station, 115V

    Micro Shaking Station, 115V
  30. Micro Shaking Station, 230V

    Micro Shaking Station, 230V

    Micro Shaking Station, 230V
  31. SiliaPrep MB, Diatomaceous Earth

    SiliaPrep MB, Diatomaceous Earth

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  32. SiliaPrep MB, Carbonate

    SiliaPrep MB, Carbonate

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  33. SiliaPrep MB, Amine (WAX)

    SiliaPrep MB, Amine (WAX)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  34. SiliaPrep MB, Carboxylic Acid (WCX)

    SiliaPrep MB, Carboxylic Acid (WCX)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  35. SiliaPrep MB, Cyano

    SiliaPrep MB, Cyano

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  36. SiliaPrep MB, Diol

    SiliaPrep MB, Diol

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  37. SiliaPrep MB, C8

    SiliaPrep MB, C8

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  38. SiliaPrep MB, C18 (17%)

    SiliaPrep MB, C18 (17%)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  39. SiliaPrep MB, TMA Chloride nec (SAX)

    SiliaPrep MB, TMA Chloride nec (SAX)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  40. SiliaPrep MB, TMA Acetate nec (SAX-2)

    SiliaPrep MB, TMA Acetate nec (SAX-2)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  41. SiliaPrep MB, Tosic Acid (SCX)

    SiliaPrep MB, Tosic Acid (SCX)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  42. SiliaPrep MB, Propylsulfonic Acid (SCX-2)

    SiliaPrep MB, Propylsulfonic Acid (SCX-2)

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  43. SiliaPrep MB, Diamine

    SiliaPrep MB, Diamine

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  44. SiliaPrep MB, Triamine

    SiliaPrep MB, Triamine

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  45. SiliaPrep MB, Thiol

    SiliaPrep MB, Thiol

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  46. SiliaPrep MB, Thiourea

    SiliaPrep MB, Thiourea

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  47. SiliaPrep MB, TAAcOH

    SiliaPrep MB, TAAcOH

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  48. SiliaPrep MB, TAAcONa

    SiliaPrep MB, TAAcONa

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  49. SiliaPrep MB, DMT

    SiliaPrep MB, DMT

    Silica-Based SPE Cartridges for SiliCycle MiniBlock
  50. SiliaPrep MB, Imidazole

    SiliaPrep MB, Imidazole

    Silica-Based SPE Cartridges for SiliCycle MiniBlock

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Filter By
Support Backbone
  1. Silica Gels (26)
  2. Polymeric Resins (7)
Family / Formats
  1. SiliaPrep™ (SPE Accessories) (1)
  2. SiliaPrep™ (SPE Cartridges) (26)
  3. SiliaPrepX™ (SPE Polymeric Cartridges) (7)
  4. Other (39)
Array
  1. Amine (1)
  2. C18 (2)
  3. C8 (1)
  4. Carbonate (1)
  5. Carboxylic Acid (WCX) (2)
  6. Cyano (2)
  7. Cysteine (1)
  8. DEAM (3)
  9. Diamine (1)
  10. Diatomaceous Earth (2)
  11. Diol (2)
  12. DMT (2)
  13. DVB (2)
  14. HLB (2)
  15. Imidazole (2)
  16. Propylsulfonic Acid (SCX-2) (1)
  17. SAX (3)
  18. SAX-2 (1)
  19. SCX (3)
  20. SCX-2 (1)
  21. Silica (2)
  22. TAAcOH (2)
  23. TAAcONa (2)
  24. Thiol (2)
  25. Thiourea (2)
  26. TMA Acetate nec (1)
  27. TMA Chloride (SAX) (1)
  28. Tosic Acid (SCX) (1)
  29. Triamine (2)
  30. WAX (3)
  31. WCX (3)
Pore Size
  1. 60 Å (30)
  2. 110 Å (1)
Endcapping
  1. Endcapped (48)
  2. Non-endcapped (5)
Cartridges Volume
  1. 4 mL (33)
  2. 10 mL (33)
Bed Weight
  1. 1000 mg (26)
  2. 200 mg (7)
  3. 500 mg (33)
Particle Size
  1. 40 µm (1)
  2. 85 µm (5)
  3. 40 - 63 µm / 230 - 400 mesh (25)

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New SiliCycle Guide for Chemical Synthesis & Purification
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