SiliCycle MiniBlock® Family
Multifunctional synthesis platforms
Originally designed by chemists and engineers at Bristol-Myers Squibb, the SiliCycle MiniBlock® Family has been further developed to address a wide range of chemistry methodologies and meet your project deadlines!
- Solution & Solid-Phase Synthesis
- Peptide Synthesis
- Library Synthesis / Combinatorial Chemistry
- Multi-Step Synthesis
- Screenings
- Scavenging Studies
- Reflux and Inerting
- Parallel Purification & Filtration
The SiliCycle MiniBlock Family is widely used by chemists in the pharmaceutical, academic, biopharma, chemical, petrochemical and polymer industries. The flexibility of the design allows chemists to rapidly configure these compact parallel reactors to fit the needs of their chemistry, whether it requires inert conditions, refluxing or cooling, allowing complete freedom to choose a synthetic route.
Furthermore, these easy-to-use reaction blocks are specially designed for parallel synthesis and screening reactions. They enable you to achieve multiple reactions simultaneously, using similar amounts of time, energy and starting materials, as it would usually require for a single experiment.
Available documentation about the SiliCycle MiniBlock Family
Features and Benefits
| Function / Specification |
SiliCycle MiniBlock |
SiliCycle MiniBlock XT |
| Solution-Phase Synthesis |
✔ |
✔ |
| Solid-Phase Synthesis |
✔ |
N/A |
| SPE |
✔ |
N/A |
| Scavenger Resins |
✔ |
✔ |
| Number of Reactors |
6, 12, 24, 48, 96 |
6, 12, 24, 48 |
| Reactors Capacity |
40 mL, 20 mL, 10 mL, 4 mL |
110 mL, 55 mL, 18 mL, 11.5 mL |
| Heating |
80°C (Polypropylene)
120°C (Glass) |
160°C |
| Cooling |
-20°C (Via Recirculator - Not Included) |
-78°C (Ice Bath)
-20°C (Via Recirculator - Not Included) |
| Inerting Capability |
✔ |
✔ |
| Reflux Capability |
N/A |
✔ |
| Mixing |
Orbital Shaking |
Stirrer Plate /
Orbital Shaking |
- SiliCycle MiniBlock: 6-Positions (40mL), 12-Positions (20mL), 24-Positions (10mL) and 48-Positions (4mL).
SiliCycle MiniBlock is a flexible, easy-to-use tool that maximizes the productivity of synthetic chemists while reducing development time. It is the only compact parallel synthesizer that allows synthesis via solid or solution-phase as well as purification to be carried out on the same platform. [read more]
- SiliCycle MiniBlock XT: 6-Positions (110mL), 12-Positions (55mL), 24-Positions (18mL) and 48-Positions (11.5mL).
The SiliCycle MiniBlock XT is an easy-to-operate system designed for parallel synthesis and screening reactions. Applications include synthesis of small organic molecules, optimization of critical process parameters, and screening for optimal reaction conditions. It is ideal for applications supported by statistical Design of Experiments (DoE). [read more]
Since the SiliCycle MiniBlock Family is fully compatible with the entire spectrum of SiliCycle scavengers (metal, organic and GPI scavengers), functionalized silica gels (such as chromatographic phases and reagents), heterogeneous catalysts and all our SPE sorbents (silica-based and polymeric): no need to look any further to find all that you will need for your projects!
View the complete MiniBlock® Family Video Library
SiliCycle MiniBlock Family in literature
See the publications
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- «Synthesis of new penicillin derivatives as drug-like molecules for biological screening»
Chin. Chem. Let., 2015, 26, 113-117
Higuchi Biosciences Center, The University of Kansas, Lawrence, USA
Department of Medicinal Chemistry, The University of Kansas, Lawrence, USA
- «Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles»
PNAS, 2011, 108, 6751-6756
Chemical Biology Platform, Broad Institute, Cambridge, United States
- «Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone Libraries [...]»
J. Comb. Chem., 2008, 10, 285-302
Department of Chemistry, University of Kansas, Kansas, United States
Center for Methodology and Library Development at the University of Kansas, Kansas, United States
- «Application of Lean Manufacturing Concepts to Drug Discovery: Rapid Analogue Library Synthesis»
J. Comb. Chem., 2006, 8, 664-669
The Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, United States
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Multi-Layer Sealing Gasket for Inert/Purge Manifold, 24-Positions, Advanced Sealing, 5/pk
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Sealing Gasket, Ultra Pure Natural Rubber, for Purge/Evap Manifold, 24-Positions, 5/pk
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Inner/Piercing Septa for Purge/Evap Manifold: 24-Positions, 5/pk
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Magnetic Stir Cross, 3/8 in, 24-positions, 30/box
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Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlock can be chosen red or blue.
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Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlock can be chosen red or blue.
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Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlocks can be chosen as one of each color (red and blue) or both blocks the same color.
Red/Blue combination is required for collection into a 96-Positions format.
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Designed to allow flexibility for reaction array and vessel volume. SiliCycle MiniBlocks can be chosen as one of each color (red and blue) or both blocks the same color.
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Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. For use with magnetic stirrer-heater (not included). Temperature range of -70°C to 160°C. Fully upgradable for reflux and inerting capability. Consumables are included in the price.
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Reactor designed for precision heating and refluxing (temperature range: -70°C to 160°C). For use with magnetic stirrer-heater (not included). Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
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Reactor designed for reflux or controlled temperature synthesis (temperature range: -70°C to 160°C). For use with magnetic stirrer-heater. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
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Reactor designed for reflux or controlled temperature synthesis (temperature range: -70°C to 160°C). For use with magnetic stirrer-heater. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
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Unique reaction block with built-in liquid circulation, allowing temperature control using a standard heating and cooling recirculator (temperature range of -70°C to 160°C). Heating and cooling of reaction vessels in one step, with a single connection. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Fully upgradable for reflux and inerting capability. Consumables are included in the price.
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Unique reaction block with built-in liquid circulation, allowing temperature control using a standard heating and cooling recirculator (temperature range of -70°C to 160°C). Heating and cooling of reaction vessels in one step, with a single connection. Small footprint, compact and space efficient reaction block. Complete synthesis system for 6 (110 mL), 12 (55 mL), 24 (18 mL) or 48 (11.5 mL) parallel solution-phase reactions. Consumables are included in the price.
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High performance orbital shaker with integrated basins for wash and rinse capability. Customized and configured to provide vigorous vortex mixing for 1 (Micro) or 2 (Compact) SiliCycle MiniBlocks.
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Patented reactor with built-in valve design. Available in 48, 24, 12, and 6-Positions arrays. Reaction vessel volumes are 4 mL, 10 mL, 20 mL and 40 mL respectively (not included).
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Heating/Cooling Block, allowing uniform cooling to -40°C, and heating to 120°C. Quick to install, efficient condensation. Available in 6, 12, 24 or 48-Positions arrays. Includes quick-disconnect fittings.
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Inert gas manifold can be operated in continuous purging or static pressure modes. Internal septum prevents evaporative loss and facilitates reagent addition or reaction sampling. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. For MiniBlock 48-Positions.
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For 6,12 and 24-Positions reactors. Provides superior performance for maintaining inert atmosphere while providing a cost effective option for evaporating solvents. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. Includes one box of sealing layer and one box of Inner/Piercing septa.
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To stack one SiliCycle MiniBlock on top of the other, allowing the transfer of products. Does not fit over heat transfer block!
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Ensure maximal uniformity between reactors when working under extreme temperatures. Temperature uniformity and reproducibility is within 1°C at 80°C.
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Simple device that helps drain reaction tubes by applying gentle air pressure.
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Provides positive pressure to all reaction tubes to assist draining. Also used to push solvents from one SiliCycle MiniBlock to a second SiliCycle MiniBlock containing resins/sorbents.
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Focuses heat from stirrer plate unit to XT reactor for uniform temperature distribution to all reaction vessels.
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Insulated tray for sub-ambient temperature control of one XT reactor. Insulated tray maintains dry ice / acetone temperature for approximately four hours without refilling. Tray can be placed on top of magnetic stirrers for mixing reaction components.
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Compact Shaking Station, 115V
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Compact Shaking Station, 230V
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Counter Weight (Compact Station)
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Micro Shaking Station, 115V
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Micro Shaking Station, 230V
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
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Silica-Based SPE Cartridges for SiliCycle MiniBlock
