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SiliCycle MiniBlock® Family

Multifunctional synthesis platforms

Originally designed by chemists and engineers at Bristol-Myers Squibb, the SiliCycle MiniBlock® Family has been further developed to address a wide range of chemistry methodologies and meet your project deadlines!

  • Solution & Solid-Phase Synthesis
  • Peptide Synthesis
  • Library Synthesis / Combinatorial Chemistry
  • Multi-Step Synthesis
  • Screenings
  • Scavenging Studies
  • Reflux and Inerting
  • Parallel Purification & Filtration

The SiliCycle MiniBlock Family is widely used by chemists in the pharmaceutical, academic, biopharma, chemical, petrochemical and polymer industries. The flexibility of the design allows chemists to rapidly configure these compact parallel reactors to fit the needs of their chemistry, whether it requires inert conditions, refluxing or cooling, allowing complete freedom to choose a synthetic route.

Furthermore, these easy-to-use reaction blocks are specially designed for parallel synthesis and screening reactions. They enable you to achieve multiple reactions simultaneously, using similar amounts of time, energy and starting materials, as it would usually require for a single experiment.

 

Available documentation about the SiliCycle MiniBlock Family

 

Features and Benefits

Function / Specification SiliCycle MiniBlock SiliCycle MiniBlock XT
Solution-Phase Synthesis
Solid-Phase Synthesis N/A
SPE N/A
Scavenger Resins
Number of Reactors 6, 12, 24, 48, 96 6, 12, 24, 48
Reactors Capacity 40 mL, 20 mL, 10 mL, 4 mL 110 mL, 55 mL, 18 mL, 11.5 mL
Heating 80°C (Polypropylene)
120°C (Glass)
160°C
Cooling -20°C (Via Recirculator - Not Included) -78°C (Ice Bath)
-20°C (Via Recirculator - Not Included)
Inerting Capability
Reflux Capability N/A
Mixing Orbital Shaking Stirrer Plate /
Orbital Shaking

 

  • SiliCycle MiniBlock: 6-Positions (40mL), 12-Positions (20mL), 24-Positions (10mL) and 48-Positions (4mL).

    SiliCycle MiniBlock is a flexible, easy-to-use tool that maximizes the productivity of synthetic chemists while reducing development time. It is the only compact parallel synthesizer that allows synthesis via solid or solution-phase as well as purification to be carried out on the same platform. [read more]

  • SiliCycle MiniBlock XT: 6-Positions (110mL), 12-Positions (55mL), 24-Positions (18mL) and 48-Positions (11.5mL).

    The SiliCycle MiniBlock XT is an easy-to-operate system designed for parallel synthesis and screening reactions. Applications include synthesis of small organic molecules, optimization of critical process parameters, and screening for optimal reaction conditions. It is ideal for applications supported by statistical Design of Experiments (DoE). [read more]

 

For more information, please contact us at: miniblock@silicycle.com

 

Since the SiliCycle MiniBlock Family is fully compatible with the entire spectrum of SiliCycle scavengers (metal, organic and GPI scavengers), functionalized silica gels (such as chromatographic phases and reagents), heterogeneous catalysts and all our SPE sorbents (silica-based and polymeric): no need to look any further to find all that you will need for your projects!

 

View the complete MiniBlock® Family Video Library

 

SiliCycle MiniBlock Family in literature

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  1. SiliaPrepX MB HLB Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0002)

    SiliaPrepX MB HLB Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0002)

    SPE Cartridges for SiliCycle MiniBlock Parallel Synthesizer. SiliaPrepX MB HLB is a wettable copolymer presenting a Hydrophobic-Lipophilic Balance (HLB) permitting a strong retention for neutral, acidic and basic compounds and a high stability in organic solvents.
  2. SiliaPrepX MB DVB Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0001)

    SiliaPrepX MB DVB Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0001)

    SPE Cartridges for SiliCycle MiniBlock Parallel Synthesizer. SiliaPrepX MB DVB is a polystyrene-divinylbenzene copolymer presenting a high hydrophobicity used as reversed-phase for extraction of neutral, acidic and basic compounds in viscous matrices.
  3. SiliaPrepX MB SCX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0005)

    SiliaPrepX MB SCX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0005)

    SPE Cartridges for SiliCycle MiniBlock Parallel Synthesizer. SiliaPrepX MB SCX is a polystyrene-divinylbenzene copolymer functionalized by a strong cation exchanger presenting a high selectivity for acids (pKa 2 - 10). It is highly stable in organic solvents.
  4. SiliaPrepX MB WCX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0015)

    SiliaPrepX MB WCX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0015)

    SPE Cartridges for SiliCycle MiniBlock Parallel Synthesizer. SiliaPrepX MB WCX is a polystyrene-divinylbenzene copolymer functionalized by a weak cation exchanger used to catch and release strong basic compounds (pKa >10). It is highly stable in organic solvents.
  5. SiliaPrepX MB SAX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0010)

    SiliaPrepX MB SAX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0010)

    SPE Cartridges for SiliCycle MiniBlock Parallel Synthesizer. SiliaPrepX MB SAX is a polystyrene-divinylbenzene copolomer functionalized by a strong anion exchanger presenting a high selectivity for acids (pKa 2 - 8). It is highly stable in organic solvents.
  6. SiliaPrepX MB WAX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0020)

    SiliaPrepX MB WAX Polymeric SPE Cartridges for SiliCycle MiniBlock (SPMB-P0020)

    SPE Cartridges for SiliCycle MiniBlock Parallel Synthesizer. SiliaPrepX MB WAX is a polystyrene-divinylbenzene copolymer functionalized by a weak anion exchanger used to catch and release strong acidic compounds (pKa <2). It is highly stable in organic solvents.
  7. SiliaPrepX MB Polymeric Development Kits for SiliCycle MiniBlock (KSPMB-K2003)

    SiliaPrepX MB Polymeric Development Kits for SiliCycle MiniBlock (KSPMB-K2003)

    Polymeric SPE Development Kits for SiliCycle MiniBlock. Phases included: HLB, DVB, SCX, WCX, SAX, WAX.

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