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SiliaPrep Tips Sorbent Selection Guide

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Molecule Application Analyte Sorbent
Small Molecules Desalting All C18; Carbon Black
Protein removal All C18; HILIC
Metal scavenging All Cysteine; DMT; Imidazole; PSA; TAAcOH; TAAcONa; Thiol; Thiourea; Triamine
Enrichment Hydrophobic C18; HLB; DVB; Carbon Black; HILIC
Hydrophilic Silica; Cyano; Carbon Black; HILIC
Neutral C18; HLB; DVB; Carbon Black; HILIC; Cyano
Cationic SCX; WCX; Polymeric SCX & WCX
Anionic SAX; NH2; Polymeric SAX & WAX
Fluorinated Compounds Fluoro
Peptides Desalting All C4; C8; C18; Carbon Black; HILIC
SDS removal All SDS Removal
Enrichment Glycopeptide Carbon Black; HILIC; TiO2
Phosphopeptide TiO2; ZrO2; TiO2/ZrO2; SAX; NH2; Polymeric SAX & WAX
Other peptide SAX; NH2; SCX; WCX; Polymeric SAX, WAX, SCX & WCX
Proteins SDS removal All SDS Removal
Tryptic digestion All Trypsin
Enrichment Phosphoprotein TiO2 ; ZrO2; TiO2 / ZrO2; SAX; NH2; Polymeric SAX & WAX
Other protein SAX; NH2; SCX; WCX; Polymeric SAX, WAX, SCX & WCX
Oligo-saccharides Desalting All Carbon Black
Enrichment Sulfated glycan SAX; XSAX
Sialo-glycan SAX; XSAX
Other oligosaccharide Carbon Black; HILIC; TiO2

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