SiliaMetS DEAM: Your last step toward uncompromised purity
Effectively eliminates trace metals and boronic acids from products
SiliaMetS DEAM is a versatile scavenger designed to remove trace metal or boronic acids from reaction intermediates or final APIs.
Metals Removed
- Best scavenger for: Ag, Fe, Sn, Ti & Zn.
- Good scavenger for: Se.
Scavengers are our class of functionalized silica that exhibit ability to bond (that is, to “scavenge”) various metal compounds or organic molecules dissolve in solution. In organic chemistry, formation of new bonds is of utmost importance and for this to be achieved, cross-coupling reactions are among the most important processes.
Initially these reactions used simple Pd-catalysts. However, the need to carry out more challenging coupling reactions has resulted in the development of more advanced catalysts and the use of many different metals.
Our SiliaMetS DEAM is your best choice for the scavenging of Titanium (Ti), and is also very powerful for Zinc (Zn), Iron (Fe) and Silver (Ag). Apart from the pharmaceutical industry, metal scavengers such as DEAM can be used in many other industries that need to recover low levels of precious metals, such as mining, refining, manufacturing, etc.
SiliaMetS DEAM is a very versatile scavenger, as it is dual-purpose: it also is a highly effective tool to remove excess boronic acids from non-aqueous solutions. Boronic acids are widely used in organic synthesis and for a vast range of biological, medicinal and synthetic applications, particularly Suzuki coupling reactions.
Our SiliaMetS DEAM is the first DEAM-silica supported on the market, and is produced in large scale in our state-of-the-art facilities.
Scheme 1. Scavenging of a boronic acid using Si-DEAM

Table 1
Scavenging activity for metals by SiliaMetS DEAM |
Complex |
Metal |
Solvent |
Scavenging Efficiency |
Pd(OAc)2 |
Pd |
DMF |
74 % |
Zn(OAc)2 |
Zn |
DMF |
96 % |
FeCl3.6H2O |
Fe |
DMF |
96 % |
Ti(OiPr)4 |
Ti |
DMF |
92 % |
AgNO3 |
Ag |
DMF |
88 % |
Table 2
Scavenging activity for phenyl boronic acid by SiliaMetS DEAM for 1h at room temperature |
Nb of eq. |
Scavenging Efficiency |
1 |
|
2 |
|
Table 3
Typical Reaction Applications for SiliaMetS DEAM in order to remove catalyst |
Reaction |
Catalyst to be scavenged |
Suzuki coupling |
boronic acid |
Lewis Acids |
TiCl4 & alkoxide derivatives |
Sakuraï reaction |
TiCl4 |
Mukayama-Aldol reation |
Knoevenagel condensation |
Reductive alkylation of 1st to 2nd amines |
TIPP |
Reductive amination of enolizable carbonyls |