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 APPLICATION NOTE 

Efficient Method for the Removal of Nickel with E-PAK

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Since its first reports in the late 1960’s, cross-coupling methods have become one of the most ubiquitous reactions for the synthesis of drug candidates. In fact, its discovery has been so groundbreaking that those involved were awarded the 2010 Nobel prize in chemistry. Among the seminal discoveries of Heck and Mizoroki in the early 1970’s,3 the works of Corriu and Kumada showcased Ni as a catalyst for a Grignard based cross-coupling reaction with aryl and alkenyl halides.

In this Application Note, a nickel‑based Kumada-Corriu coupling reaction was followed by the scavenging of nickel. The efficiency of activated carbons and SiliaMetS metal scavengers, as well as their use with the E-PAK technology for the capture of nickel is demonstrated.

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Find below the list of SiliCycle's products involved in this Application Note:

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  1. SiliaMetS Triamine metal scavenger (R48030B)

    SiliaMetS Triamine (R48030B)

    Effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
  2. SiliaMetS DMT (Dimercaptotriazine) (R79030B)

    SiliaMetS DMT (Dimercaptotriazine) (R79030B)

    SiliaMetS DMT is the silica - bound equivalent of 2,4,6 - trimercaptotriazine (trithiocyanuric acid, TMT). It is a versatile metal scavenger for a variety of metals and the preferred metal scavenger for ruthenium catalysts and hindered Pd complexes. Best scavenger for: As, Ir, Ni, Os, Pd, Pt, Rh, Ru & Se. Good scavenger for: Cd, Co, Cu, Fe, Sc & Zn.
  3. SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals under a wide range of conditions and the preferred metal scavenger for iron catalysts. Best scavenger for: Cd, Co, Cu, Fe, Ir, Li, Mg, Ni, Os, W & Zn. Good scavenger for: Cr, Pd & Rh. It can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
  4. Laboratory Scale SiliaMetS® Thiol E-PAK® Cartridges for metal purification
  5. Laboratory Scale SiliaCarb CA Activated Carbon E-PAK® Cartridges for purification
  6. Housing Kit for 5 x 1 cm Laboratory Scale E-PAK Cartridges (LSHK-1)
  7. Laboratory Scale SiliaMetS® Triamine E-PAK® Cartridges for metal purification
  8. Laboratory Scale SiliaMetS® Imidazole E-PAK® Cartridges for metal purification
  9. Laboratory Scale SiliaMetS® Diamine E-PAK® Cartridges for metal purification

    E-PAK Cartridges, SiliaMetS Diamine, 5 x 1 cm

    Best scavenger for: Cr, Pd, Pt, W & Zn / Good scavenger for: Cd, Co, Cu, Fe, Hg, Ni, Pb, Ru, Sc, Se & V

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