SiliaBond Cyanoborohydride as a Reducing Agent

> back to Application Notes

SiliaBond Cyanoborohydride (CBH) is the silica-bound equivalent of sodium cyanoborohydride. This reagent is known to be very effective for reductive amination and for the reduction of imines. It also allows the reduction of α, β - unsaturated carbonyls to their corresponding unsaturated alcohols. However, cyanide contamination resulting from the use of this reagent is of concern due to its high toxicity, and this may have a deterrent effect on its use. Fortunately, this problem could be minimized using a silica-supported version since the toxic cyanide residue remains on the solid support.

Download our Application note

Find below the list of SiliCycle's products involved in this Application Note: