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 APPLICATION NOTE 

SiliaBond TMA Acetate (SAX-2) Silica Used in SiliaPrep SPE Cartridges

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Silica-based SAX sorbents are usually produced with a high selectivity chloride counter ion but these offer reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate. Therefore, users traditionally perform the exchange of the chloride ion prior to sample loading. This process can be time consuming and may not have allowed total exchange. To this end, SiliCycle has developed SiliaBond TMA Acetate (SAX-2), a strong anion exchange sorbent with a low selectivity acetate counter ion already in place.

Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range.

SiliaBond TMA Acetate (SAX-2), is a strong anion exchange sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas < 5, such as carboxylic acid. This property can be used in synthetic chemistry applications to selectively purify acidic compounds or remove acidic impurities from reaction mixtures. This application note will highlight the properties of this product and show a series of applications in synthesis using this material in SPE format.

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  1. SiliaPrep SPE Cartridges, TMA Acetate (SAX-2) nec (SPE-R66430B)

    SiliaPrep SPE Cartridges, TMA Acetate (SAX-2) nec (SPE-R66430B)

    SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.

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