APPLICATION NOTE
Silica-based SAX (Strong Anion Exchange) sorbents are usually paired with a high selectivity chloride counter-ion which offers reduced retention of acidic drugs compared to sorbents paired with counter-ions of lower selectivity such as the acetate one. Consequently, users traditionally perform themselves the exchange of counter-ion prior to sample loading. This process can be time consuming and may actually lead to an incomplete exchange. As a result, SiliCycle has developed SiliaPrep SAX-2 (TMA Acetate): SPE cartridges packed with a strong anion exchange sorbent paired with a low selectivity acetate counter-ion.
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SiliaPrep SAX-2 nec (TMA Acetate) SPE Cartridges
Silica-based SAX (Strong Anion Exchange) sorbents are usually paired with a high selectivity chloride counter-ion which offers reduced retention of acidic drugs compared to sorbents paired with counter-ions of lower selectivity such as the acetate one. Consequently, users traditionally perform themselves the exchange of counter-ion prior to sample loading. This process can be time consuming and may actually lead to an incomplete exchange. As a result, SiliCycle has developed SiliaPrep SAX-2 (TMA Acetate): SPE cartridges packed with a strong anion exchange sorbent paired with a low selectivity acetate counter-ion.
This Application Note highlights the properties of this sorbent and reveals a series of applications using this phase in SPE format, to easily separate weak acids from strong ones.
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SiliaPrep SPE Cartridges, TMA Acetate (SAX-2) nec (SPE-R66430B)
SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.
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