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 APPLICATION NOTE 

Suzuki Catalysts Scavenging Study with Activated Carbon and SiliaMetS

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In recent years, the removal of post-reaction residues has become a major issue in the pharmaceutical industry. For several years, SiliCycle has offered SiliaMetS metal scavengers allowing customers to achieve this goal. SiliCycle now offers a new proprietary technology called E-PAK to purify API from residual metals. Tests were conducted to measure the efficiency of the E-PAK technology with SiliaMetS and activated carbon to remove Pd(Ph3)4 from a Suzuki coupling reaction. Screening tests in bulk were performed in a multi-reaction apparatus to select the best sorbents. In this Application Note, we demonstrate the direct and straightforward transfer from bulk to E-PAK for the removal of palladium.

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Find below the list of SiliCycle's products involved in this Application Note:

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  1. SiliaMetS Triamine metal scavenger (R48030B)

    SiliaMetS Triamine (R48030B)

    Effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
  2. SiliaMetS Diamine (R49030B)

    SiliaMetS Diamine (R49030B)

    SiliaMetS is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates. Best metal scavenger for: Cr, Pd, Pt, W & Zn. Good scavenger for: Cd, Co, Cu, Fe, Hg, Ni, Pb, Ru, Sc, Se & V.
  3. SiliaMetS Thiol (SH) (R51030B)

    SiliaMetS Thiol (SH) Metal Scavenger (R51030B)

    Our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions. Best scavenger for: Ag, Hg, Os, Pd & Ru. Good scavenger for: Cu, Ir, Pb, Rh, Se & Sn.
  4. SiliaMetS TAAcONa nec (R69230B)

    SiliaMetS TAAcONa nec (R69230B)

    SiliaMetS TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.
  5. SiliaMetS Thiourea (THU) (R69530B)

    SiliaMetS Thiourea (THU) (R69530B)

    SiliaMetS Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium, and is widely used in the pharmaceutical industry. Once complexed with a transition metal, it has also been reported as being an effective catalyst. Best scavenger for: Pd & Ru. Good scavenger for: Ag, Cu, Fe, Os, Rh, Sc & Sn.
  6. SiliaMetS DMT (Dimercaptotriazine) (R79030B)

    SiliaMetS DMT (Dimercaptotriazine) (R79030B)

    SiliaMetS DMT is the silica - bound equivalent of 2,4,6 - trimercaptotriazine (trithiocyanuric acid, TMT). It is a versatile metal scavenger for a variety of metals and the preferred metal scavenger for ruthenium catalysts and hindered Pd complexes. Best scavenger for: As, Ir, Ni, Os, Pd, Pt, Rh, Ru & Se. Good scavenger for: Cd, Co, Cu, Fe, Sc & Zn.
  7. SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals under a wide range of conditions and the preferred metal scavenger for iron catalysts. Best scavenger for: Cd, Co, Cu, Fe, Ir, Li, Mg, Ni, Os, W & Zn. Good scavenger for: Cr, Pd & Rh. It can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
  8. SiliaMetS Cysteine (CYS) (R80530B)

    SiliaMetS Cysteine (CYS) (R80530B)

    SiliaMetS Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.
  9. SiliaMetS DEAM (R54430B)

    SiliaMetS DEAM (R54430B)

    SiliaMetS DEAM is a versatile scavenger designed to remove trace metal or boronic acids from reaction intermediates or final APIs. Best scavenger for: Ag, Fe, Sn, Ti & Zn. Good scavenger for: Se.
  10. SiliaChrom Plus HPLC Columns, C18, 5 µm, 100 Å (HPL-S03205E-A)

    SiliaChrom Plus HPLC Columns, C18, 5 µm, 100 Å (HPL-S03205E-A)

    SiliaChrom Plus C18 columns will help you with your everyday separations. They are a great start for method development as they present maximum retention for non-polar compounds.

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