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Use Of SiliaBond® Carbonate

SiliaBond® Carbonate (or Si-CO3) is the silica bound equivalent of tetramethylammonium carbonate. It can be used as a general base to quench a reaction, to free base amine hydrochlorides and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions. SiliaBond Carbonate is also very efficient at scavenging boronic acids: 99% of phenylboronic acid is removed with 1 equivalent of Si-CO3 in DCM at RT, after 1 h.

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