Download our Case Study- > Offre d'emploi: Designer Graphique
- > It’s not just about the shape – Handy guide to (other) common problems in HPLC
- > How to get the perfect shape according to experts – Top 6 most common shape problems in HPLC
- > Some People Excel at Scaling Up Their Purifications and Some Don’t, Which One Are You?
- > Loading in Progress – Avoiding loading capacity mistakes
CASE STUDY
Enantiomer N-1 Substituted Tetrazole Prodrug Synthesis
The authors of the study performed a regioselective tin-mediated alkylation to access the N-1 alkylated tetrazole isomer. A highly selective enzymatic hydrolysis provided the desired prodrug enantiomer. For the final fragment union, a Suzuki–Miyaura coupling was employed, leading to the need to eliminate both tin and residual palladium catalyst from the API in multikilogram quantities.
Our Most Popular Categories
Our New Products
