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 CASE STUDY 

Screening of Various Metal Scavengers for Copper Removal in the Synthesis of a Bicyclo Derivative

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Azide-alkyne cycloadditions are pioneering reactions to click chemistry as they fulfill many of the prerequisites & principles this new chemical philosophy is aiming for.

More specifically, copper-catalyzed azide–alkyne cycloadditions (CuAAC) are important reactions for the generation of bioactive molecules. However, as we know copper salts are toxic toward living systems and have deleterious effects on redox-sensitive nanoparticles which is why their removal after conjugation is important. In this case study a more elegant strategy is herein described eliminating the need for EDTA or dialysis often found in the clasical protocols. Following a terminal alkyne-selective click conjugation with azides, Prof. Hosoya and co-workers screened various metal scavengers in order to select the most potent chelator in the removal of copper.

SiliaMetS® Thiourea was shown to be the most valuable, among other SiliCycle Metal Scavengers and a PS-TPP resin.

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Discover our 3 metal scavengers that were screened in this study:

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  1. SiliaMetS Thiourea (THU) (R69530B)

    SiliaMetS Thiourea (THU) (R69530B)

    SiliaMetS Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium, and is widely used in the pharmaceutical industry. Once complexed with a transition metal, it has also been reported as being an effective catalyst. Best scavenger for: Pd & Ru. Good scavenger for: Ag, Cu, Fe, Os, Rh, Sc & Sn.
  2. SiliaMetS Triamine metal scavenger (R48030B)

    SiliaMetS Triamine (R48030B)

    Effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
  3. SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (IMI) (R79230B)

    SiliaMetS Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals under a wide range of conditions and the preferred metal scavenger for iron catalysts. Best scavenger for: Cd, Co, Cu, Fe, Ir, Li, Mg, Ni, Os, W & Zn. Good scavenger for: Cr, Pd & Rh. It can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

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