Efficient Method for the Removal of Nickel with E-PAK

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Since its first reports in the late 1960’s, cross-coupling methods have become one of the most ubiquitous reactions for the synthesis of drug candidates. In fact, its discovery has been so groundbreaking that those involved were awarded the 2010 Nobel prize in chemistry. Among the seminal discoveries of Heck and Mizoroki in the early 1970’s,3 the works of Corriu and Kumada showcased Ni as a catalyst for a Grignard based cross-coupling reaction with aryl and alkenyl halides.

In this Application Note, a nickel‑based Kumada-Corriu coupling reaction was followed by the scavenging of nickel. The efficiency of activated carbons and SiliaMetS metal scavengers, as well as their use with the E-PAK technology for the capture of nickel is demonstrated.

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