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Scaling up a Sonogashira Reaction with E-PAK

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Among the numerous types of cross-coupling reactions, the Sonogashira coupling of aryl halides with terminal alkynes stands out for its use in the synthesis of complex molecules, such as eneyne-based natural products. This Application Note showcases the ease of scalability of the E-PAK technology with a Pd purification from a Sonogashira reaction for the synthesis of a halogenated TMS protected ethynyl aniline.

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