APPLICATION NOTE
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Scaling up a Sonogashira Reaction with E-PAK

Among the numerous types of cross-coupling reactions, the Sonogashira coupling of aryl halides with terminal alkynes stands out for its use in the synthesis of complex molecules, such as eneyne-based natural products. This Application Note showcases the ease of scalability of the E-PAK technology with a Pd purification from a Sonogashira reaction for the synthesis of a halogenated TMS protected ethynyl aniline.

Find below the list of SiliCycle's products involved in this Application Note:
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E-PAK Cartridges, Lab Scale, SiliaCarb VW Activated Carbon, 5 x 1 cm
Virgin Wood Activated Carbon -
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E-PAK Cartridges, Lab Scale, SiliaCarb VW Activated Carbon, 5 x 10 cm
Virgin Wood Activated Carbon -
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E-PAK Cartridges, Lab Scale, SiliaCarb VW Activated Carbon, 5 x 25 cm
Virgin Wood Activated Carbon