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Screening and Efficient Removal of Ruthenium 3rd Generation Grubbs Catalyst

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With the increasing use of metathesis in the pharmaceutical industry, the removal of the metal catalyst has become a focus. One of the most popular metals as a catalyst is ruthenium, due to being air stable, highly active and versatile for all types of metathesis. To investigate the efficiency of the SiliaCarb activated carbons and SiliaMetS metal scavengers at removing ruthenium, a ring-closing metathesis was performed using the 3rd generation Grubbs catalysts on a functionalized diene. This Application Note details the screening of the bulk SiliaCarb and SiliaMetS as well as the experimental conditions to be transferred to E-PAK.

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Useful links related to this application note:

Complete SiliaMetS metal scavengers portfolio

Complete E-PAK cartridges portfolio (including SiliaCarb)