Scavenging of the Residual Buchwald-Hartwig Catalyst with SiliaMetS^® Thiol

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The efficiency of the Buchwald-Hartwig catalyst to achieve C-N bond formation makes it very frequently used in organic synthesis, however its high cost and limited supply is less attractive for multigram-scale C−N bond formation. In this article, researchers explored using the catalyst for the C-N cross-coupling of aryl amines with aryl halides in a biphasic aqueous solution. This approach allowed for an efficient synthesis with high yields to be achieved for kilogram-scale reactions.

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