Follow SiliCycle on Facebook Follow SiliCycle on Twitter Follow SiliCycle on LinkedIn Watch our videos on Youtube

Scavenging of the Residual Buchwald-Hartwig Catalyst with SiliaMetS® Thiol

> back to Case Studies

The efficiency of the Buchwald-Hartwig catalyst to achieve C-N bond formation makes it very frequently used in organic synthesis, however its high cost and limited supply is less attractive for multigram-scale C−N bond formation. In this article, researchers explored using the catalyst for the C-N cross-coupling of aryl amines with aryl halides in a biphasic aqueous solution. This approach allowed for an efficient synthesis with high yields to be achieved for kilogram-scale reactions.

Download our Case Study

Need more help? Talk to a scavenging expert at [email protected]


Find below the list of our various SiliaMetS Thiol products: