Screening of Various Metal Scavengers for Copper Removal in the Synthesis of a Bicyclo Derivative

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Azide-alkyne cycloadditions are pioneering reactions to click chemistry as they fulfill many of the prerequisites & principles this new chemical philosophy is aiming for.

More specifically, copper-catalyzed azide–alkyne cycloadditions (CuAAC) are important reactions for the generation of bioactive molecules. However, as we know copper salts are toxic toward living systems and have deleterious effects on redox-sensitive nanoparticles which is why their removal after conjugation is important. In this case study a more elegant strategy is herein described eliminating the need for EDTA or dialysis often found in the clasical protocols. Following a terminal alkyne-selective click conjugation with azides, Prof. Hosoya and co-workers screened various metal scavengers in order to select the most potent chelator in the removal of copper.

SiliaMetS® Thiourea was shown to be the most valuable, among other SiliCycle Metal Scavengers and a PS-TPP resin.

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Discover our 3 metal scavengers that were screened in this study: