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Simple and Effective Removal of Boronic Acids after Newly Reported Mutagenic Activity
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Up to very recently, boronic acids had always been reported as lacking apparent toxicity, mutagenic activity or in vivo instability issues. New studies have raised objections about this safe toxicological profile, both based on experimental and clinical data. SiliCycle produces and commercializes silica-based heterogeneous scavengers for both metallic and organic impurities. SiliaBond DEAM and Diol have shown to be powerful and very effective scavengers for the removal of boronic acids.
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Get ready for the ICH-Q3D Heavy Metal Regulation
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In recent years, the presence of metal impurities has become a major issue in the drug-making industry, and thus, the need for its effective removal. For almost two years now, the International Conference on Harmonisation (ICH) has been working on its Q3D guidelines for metal elemental impurities in new drugs and new formulations containing known ingredients. After many revisions and improvements, the final version or the Q3D guidelines was finally accepted and signed off by the ICH Steering Committee in December 2014, hence requiring that the entire manufacturing industry and supply chain follow these regulations.
